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201,169 grants found
Showing 196,681 – 196,700 of 201,169 grants
Under-oil open microfluidic system (UOMS) for studying systemic fungal infection
Project Summary/Abstract Opportunistic fungal pathogens are a leading cause of healthcare associated bloodstream infections. Candida yeasts, specifically, cause 80-90% of biofilm-a...
Secondary data analysis of auditory steady-state response to explore the RDoC cognitive system constructs across the psychosis spectrum
Hallucinations and cognitive impairments associated with psychosis may be underpinned by N-methyl D- aspartate (NMDA) receptor hypofunction. Within the Research Domain Criteria (RD...
Enabling nationwide AD PET imaging to support most efficient clinical trials by adoption of radically simplified and standardized quality control in commercial production of AD PET tracers.
Positron Emission Tomography (PET) is the most powerful imaging procedure relied upon in the management ofAlzheimer’s Disease (AD). It provides information on the molecular process...
Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer
Project Summary/Abstract Current AR inhibitors (enzalutamide and abiraterone) inhibit either the conversion of androgen to dihydrotestosterone (DHT), block androgen binding to andr...
Regulators of ubiquitin signaling in malignant hematopoiesis
Project Summary / Abstract Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem and progenitor cell (HSPC) disorders with frequent transformation to acute my...
Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding
ABSTRACT The proteostasis network relies on numerous feedback mechanisms to strike a balance between the rates of protein synthesis and degradation, which is crucial for the mainte...
Embryonic vascular stem-progenitors for treatment of ischemic retinopathies
Branch vein occlusion (BVO) and diabetic retinopathy (DR) are major causes of new onset blindness in the US. These vascular disorders result in acellular capillaries secondary to i...
Tissue factor-dependent coagulation in thrombosis and immune responses
Tissue factor (TF) is a transmembrane protein that functions as a high-affinity receptor for factor (F)VII and FVIIa. The TF-FVIIa complex is the primary initiator of coagulation a...
Effects of cell-type specific brain stimulation in Alzheimer's model mice
Project Abstract. Alzheimer’s disease is the most common neurodegenerative disorder and the leading cause of dementia in the elderly. Aberrant brain activity has become recognized...
Characterizing the primary olfactory subregions of the human amygdala
Several subregions of the human amygdala receive direct projections from the olfactory bulb, yet the functional and anatomical properties of these olfactory projections are not wel...
The Impact of Thrombosis and Antithrombotic Therapy on Peripheral Artery Disease
The applicant, Aaron W. Aday, MD, is an Instructor of Medicine in the Division of Cardiovascular Medicine at Vanderbilt University Medical Center. The applicant's goal is to b...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Fortilin, CTNNA3, and the Heart
Project Summary The main goal of this grant proposal titled “Fortilin, CTNNA3, and the Heart” is to test the central hypothesis that the inability of the failing heart to maintain...
IMSD at Rutgers - New Brunswick
Abstract/Summary This T32 IMSD proposal aims to increase the pool of PhD scientists from underrepresented (UR) backgrounds who contribute and have a significant impact on the healt...
IMSD at Rush University
Project summary/abstract: National data on career choices of emerging scientists indicate that less than 25% pursue a traditional independent pathway in an academic environment. Th...
Integrated proteomic and metabolomics analysis of thrombotic myocardial infarction
Project Summary / Abstract: Acute myocardial infarction (MI) is defined as myocardial ischemia, the inadequate supply of blood to heart muscle, followed by myocardial cell death. M...
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen species
Modified Project Summary/Abstract SectionElevated levels of reactive oxygen species (ROS) are strongly linked to severe pathological conditions causing cardiomyopathies and neurode...
Glutamatergic basal forebrain neurons in aversion-resistant drinking
Project Summary A hallmark of alcohol use disorder is continued seeking and consumption of alcohol despite negative consequences. Neuroadaptations in corticostriatal projections to...
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
SUMMARY Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism. Iron is an essential trace mineral, involved in many vital cellular and organismal functions. Organisma...
Characterizing Human RPE Cell Proliferation to Advance Endogenous Regeneration
Project Summary / Abstract Decades of study have demonstrated that adult human retinal pigment epithelium (RPE) cells have strong proliferative capacity in vitro, which indicates t...