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201,169 grants found
Showing 196,701 – 196,720 of 201,169 grants
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a disease of the pulmonary arterial vasculature and its remodeling, in which patient mortality is significantly associated...
Targeting vulnerabilities of PPM1D-mutant gliomas
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments. We and others have observed up to 15% of all DMGs to...
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...
Sex differences in cholinergic regulation of nicotinic acetylcholine receptor modulation of local nucleus accumbens circuitry underlying motivation
Project Summary/Abstract Candidate: My long term goal is to become an independent investigator running an interdisciplinary and collaborative research team to understand the mechan...
Re-purposing beta-blockers to improve chemotherapy response
ABSTRACT Metastatic tumors often develop chemoresistance, which makes chemotherapy ineffective. We have exciting evidence that beta-blockers, which are widely used cardiac drugs, c...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8–16 months, and few therapies offer a significant improvement in overall survival. However, immunother...
A large animal model to elucidate the role of LGR5 stem cells in cancer
Project Summary In the United States, colorectal cancer (CRC) is the 3rd leading cause of cancer death among women and men combined, with of 1 in 20 people being diagnosed with CRC...
Cardiac Lineage-Specific Molecular Mechanisms of Heart Failure
Project Summary The heart consists of a multitude of diverse cardiac cell types, including but not limited to cardiomyocytes, cardiac fibroblasts, epicardial cells, endothelial/end...
Harnessing Glycoproteomics and Glycomics to Understand Cardiac Biology and Disease
ABSTRACT Our research program develops and applies innovative mass spectrometry technologies, bioinformatics tools, and methodologies to transform our understanding of cell surface...
The Effect of Screening and Referral for Social Determinants of Health on Veterans' Outcomes
Background: Despite medical advances, up to 70% of health outcomes are due to social determinants of health (SDoH) - the conditions in which people live and work that shape whether...
Mechanisms of exacerbation of COVID-19 pathogenesis in mice expressing human ACE2 by polycyclic aromatic hydrocarbons (PAHs), and its protection by inhibition of soluble epoxide hydrolase (sEH)
Project Summary Severe coronavirus disease (COVID-19) is caused by a novel Beta-coronavirus, now named SARS-CoV-2. COVID-19 is characterized by unresolved systemic hyperinflammatio...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Re-engagement at Discharge (Re-Charge): Improving post-hospital outcomes for HIV-infected adults in Zambia
PROJECT SUMMARY In sub-Saharan African countries, HIV-infected patients suffer high rates of loss-to-follow-up and mortality following hospital admission. Among HIV-infected patien...
Neutralizing the degenerate disc microenvironment to enhance the efficacy of therapeutic stem cells
Abstract Low back pain is the leading cause of disability in the United States, with an estimated socioeconomic cost exceeding $100 billion each year. Intervertebral disc degenerat...
Sequence-universal high-frequency prospective MRI motion correction with navigators
Project Summary/Abstract Motion during magnetic resonance imaging (MRI) is estimated to cost hospitals approximately $115,000 per scanner per year, which implies that the annual co...
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
SUMMARY Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism. Iron is an essential trace mineral, involved in many vital cellular and organismal functions. Organisma...
Harnessing multiplexed Cas9 genome editing for sequential genetic manipulations and recording activities in cell lineages
SUMMARY Time is a problem for biologists, especially for those interested in cancer, stem cell, and developmental biology. Whereas cellular processes occur in real time, we most of...
Polyunsaturated fatty acids and colorectal tumor risk: a molecular and genetic epidemiology study
PROJECT SUMMARY/ABSTRACT Arachidonic acid, a long-chain ω-6 polyunsaturated fatty acid (PUFA), has been demonstrated to affect carcinogenesis in animal and in vitro studies. The ef...
Determining the neural and biomechanical contributions to age-dependent impairments in balance control
PROJECT SUMMARY Impaired mobility is the leading cause of disability among older adults, impacting independence and quality of life. The ability to maintain balance in response to...
The influence of task context on neural population activity during natural scene discrimination
PROJECT SUMMARY/ABSTRACT Environmental context heavily influences our visual perception, allowing us to extract relevant information from the overwhelming amount of sensory input f...