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201,169 grants found
Showing 196,721 – 196,740 of 201,169 grants
Targeting Integrins in Lung Cancer
Lung cancer is the most common cause of cancer-related deaths in US veterans and worldwide. Molecularly targeted therapy and immunotherapy are two recent major breakthroughs in lun...
Regulation of spore peptidoglycan modification
SUMMARY The bacterial pathogen, Clostridioides difficile, has been designated an urgent threat to the US healthcare system by the Centers for Disease Control. In order for C. diffi...
Translational Modeling of Brain Injury Rehabilitation to Maximize Recovery.
The motivating force driving me to build an independent research enterprise has been my personal desire to maximize functional recovery after traumatic brain injury (TBI). Experien...
Optical Analogs to MRI Contrast Agents for Surgical Guidance of Brain Tumor Resection
ABSTRACT Surgical resection is a fixture in the treatment of intracranial tumors, and there is mounting data indicating that overall and progression-free survival improve for gross...
Mechanisms for building and remodeling microtubule arrays
Project Summary Control of the internal organization of cells is essential to the form and function of all organisms. This ability rests largely on an intricate protein filament ne...
Drug-drug interactions and kidney disease in hospitalized patients
PROJECT SUMMARY As polypharmacy becomes increasingly common in patients with kidney disease, drug-drug interactions (DDIs), the phenomenon of one drug altering the effect of anothe...
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill Children
SUMMARY Lower respiratory tract infections (LRTI) lead to more deaths each year in children than any other infectious disease category. Despite this, the underlying microbial patho...
Understanding the effects of p97 protein-protein interactions on cellular functions using antibody-based inhibitors
Project Summary/Abstract Protein-protein interactions (PPIs) connect various proteins to achieve critical cellular functions. For instance, the ubiquitously expressed protein valos...
Mechanism Shaping the Adhesion Landscape During Spinal Cord Development
PROJECT SUMMARY An important question in developmental biology is how cell fate specification and cell movement are coordinated during tissue morphogenesis to ensure all cell types...
The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis
Project Summary Identification of molecular pathways that are preferentially employed and relied upon by cancer cells compared to normal cells is key to designing novel personalize...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
TGF-Beta Regulates CFTR-Mediated Airway Smooth Muscle Dysfunction
PROJECT SUMMARY/ABSTRACT Cystic fibrosis (CF) is a lethal genetic disorder characterized by progressive lung disease and airway obstruction. CF is caused by mutations in the CF tra...
Structural Studies of Macromolecular Assemblies Using Cryo-EM
Project Summary/Abstract The main objective of the proposed studies is the elucidation of fundamental processes of translation, translational regulation and translational quality c...
Development of a rapid, pan fungal diagnostic assay
ABSTRACT Diagnosing fungal infections faces a number of challenges including a decline in expertise needed for identifying fungi and a reduced number of instruments and assays spec...
Under-oil open microfluidic system (UOMS) for studying systemic fungal infection
Project Summary/Abstract Opportunistic fungal pathogens are a leading cause of healthcare associated bloodstream infections. Candida yeasts, specifically, cause 80-90% of biofilm-a...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Priming the Rehabilitation Engine: Aerobic Exercise as the Fuel to Spark Behavioral Improvements in Stroke
Stroke is a leading cause of disability in the United States and poses a significant burden to Veterans. The effectiveness of current intervention approaches is limited and many in...
IMSD at Rutgers - New Brunswick
Abstract/Summary This T32 IMSD proposal aims to increase the pool of PhD scientists from underrepresented (UR) backgrounds who contribute and have a significant impact on the healt...
Integrated proteomic and metabolomics analysis of thrombotic myocardial infarction
Project Summary / Abstract: Acute myocardial infarction (MI) is defined as myocardial ischemia, the inadequate supply of blood to heart muscle, followed by myocardial cell death. M...