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201,169 grants found
Showing 196,781 – 196,800 of 201,169 grants
Characterizing the primary olfactory subregions of the human amygdala
Several subregions of the human amygdala receive direct projections from the olfactory bulb, yet the functional and anatomical properties of these olfactory projections are not wel...
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related Structure
Project Summary Glaucoma is the second leading cause of blindness globally, and is characterized by optic nerve damage that leads to the death of retinal ganglion cells with accomp...
Mitochondrial Dynamics and Steroidogenesis
Candidate - The following application is intended to initiate the research career of Michele Plewes, PhD, within the VA Nebraska Iowa Health Care System under the mentorship of Joh...
Network For Emotional Wellbeing And Brain Aging (NEW Brain Aging)
Project summary: Early evidence indicates an association between emotional (eudaimonic and hedonic) well- being (EWB) and underlying brain processes, and that those processes chang...
The Role of the Tau in Homeostatic Scaling and Mechanisms of Alzheimer's Disease
Project Summary Little is unknown about the mechanisms involved in the regulation of neuronal network activity by the microtubule associated protein tau, a key pathogenic protein i...
The impact of the environment on sensorimotor cortex in rats: Functional organization, connections and behavior
The emergence of the neocortex and its capacity to be shaped by early sensory and motor experience is the hallmark of mammalian brain evolution. This remarkable plasticity allows t...
Global control of co-transcriptional splicing
Alternative splicing (AS) of human genes is pervasive and greatly expands the repertoire of protein and RNA products arising from the human genome. AS is critical for cellular diff...
The role of CELF2 and its genetic variants in Alzheimer's disease
Age is the most important risk factor for Alzheimer's disease (AD), but the occurrence of this disease is also affected by environmental factors, individual experience and gen...
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...
Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
SUMMARY / ABSTRACT With current treatment options, the five-year survival rate of patients with glioblastoma (GBM) is only 5%. Oncolytic viruses are promising treatments against so...
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
On differentiating selective and neutral evolutionary processes
ABSTRACT At the founding of population genetics in the early 20th century, S. Wright and R.A. Fisher developed much of the mathematical and conceptual framework underlying the stud...
Myeloid TLR4 epigenetic regulation and signaling in accelerating venous thrombus resolution
PROJECT ABSTRACT This proposal describes the 5-year training program for development of a research career in vascular biology, with focus on thrombosis. The candidate, Dr. Andrea O...
Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
Project Summary The lack of specific targets for the treatment of triple-negative breast cancer (TNBC) is a major challenge, as many TNBCs do not respond to cytotoxic chemotherapie...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Deep tensor genomic imputation
Project Summary/Abstract High-throughput sequencing assays allow scientists to measure biochemical properties like transcription factor binding, histone modifications, and gene expr...
Systemic delivery of siRNA by Nanosac for checkpoint blockade immunotherapy of head and neck squamous cell cancer
ABSTRACT Head and neck cancer is currently treated by concomitant chemotherapy and radiation, but local recurrence and metastatic disease remain a concern. In particular, there is...
Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is the fourth lethal cancer in the U.S. with a 5-year survival rate of only ~10%. The mainstay of therapy in PDA is chemother...
Initiative for Maximizing Student Development (IMSD) at Vanderbilt
The Initiative for Maximizing Student Development at Vanderbilt University (V-IMSD) seeks to continue advancing diversity and inclusion in our PhD graduate programs. V-IMSD is firm...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...