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201,169 grants found
Showing 196,801 – 196,820 of 201,169 grants
Network to Advance the Study of Mechanisms Underlying Mind-Body Interventions and Measurement of Emotional Wellbeing
ABSTRACT Although the critical role of Emotional Well-Being (EWB; e.g., life satisfaction, happiness, meaning and purpose, positive emotions) in public health is increasingly ackno...
Imaging Genetics of Brain Structure and Cognitive Aging in Murine Models of Alzheimer's Disease
Age-related cognitive decline (ARCD), Alzheimer disease (AD), and late-onset AD-related pathologies are linked to changes in brain structure, cell populations, synapse densities an...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...
Imaging Modulation of Immune Phenotype
Imaging and modulation of immunophenotype Most importantly, we have created TLR delivery nanotherapeutics and find that TLR NPs combined with aCD40, aPD-1 and aCTL4 (abbreviated as...
Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthma
Asthma is characterized by excessive bronchoconstriction and a heightened sensitivity to inhaled irritants. Airway nerves control these responses. Recently, we found that eosinophi...
Training Program in Resuscitation Science
Abstract We aim to provide advanced multidisciplinary research training in the emerging field of resuscitation science to physician- and PhD-scientists to jump-start their progress...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Localization and regulation of metabolic gene expression in response to dietary triglycerides
Abstract: The metabolic response to meals high in fat and cholesterol requires the coordination of a complex system of cellular processes. Disruption of these cellular processes ca...
Artificial intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Keratoplasty (AUTO-DALK)
PROJECT SUMMARY Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-i...
Spatial and nonspatial knowledge
Project Summary The ability to navigate from one place to another is essential for a flourishing and autonomous human life. Cognitive scientists have long believed that navigation...
Development of multifunctional drug and immune modulator delivery nanoparticles for the treatment of cancer patients with comorbid atherosclerosis
Project Summary Cancer and cardiovascular disease are leading causes of death in the United States. Given the high percentage of cancer patients with co-existing atherosclerosis, t...
Sleep-dependent modulation of cerebrospinal fluid flow in aging
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions. Disrupted sleep is now thought to not just b...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Targeting Integrins in Lung Cancer
Lung cancer is the most common cause of cancer-related deaths in US veterans and worldwide. Molecularly targeted therapy and immunotherapy are two recent major breakthroughs in lun...
The contributions of interaurally correlated signals and interaurally symmetric place of stimulation for the binaural auditory system
PROJECT SUMMARY / ABSTRACT Binaural hearing provides substantial benefits in complex listening environments, improving the ability to understand speech and providing the ability to...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
Immunotherapy for Ocular Surface Diseases
ABSTRACT We have discovered a new mechanism for inflammation on the ocular surface. First, we discovered the presence of neutrophil extracellular traps (NETs) on the ocular surface...
Restoring Vision with High-Fidelity Nonsense Codon Correction
PROJECT SUMMARY/ABSTRACT Nonsense mutations cause approximately 15% of genetically inherited retinopathies and inherited human diseases in general, accounting for 2.5 to 3 million...
The role of CELF2 and its genetic variants in Alzheimer's disease
Age is the most important risk factor for Alzheimer's disease (AD), but the occurrence of this disease is also affected by environmental factors, individual experience and gen...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...