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201,169 grants found
Showing 196,821 – 196,840 of 201,169 grants
Role of phosphate availability in lung cancer invasion and bone metastasis
PROJECT SUMMARY Metastatic dissemination is a leading cause of death from cancer with metastasis to bone represents a particularly poor prognosis. Unfortunately, metastasis to bone...
Nuclear Organization and Function
PROJECT SUMMARY. Proper regulation of gene expression is essential for cell differentiation and homeostasis. Most of our understanding of the mechanisms that control the transcript...
TRP channels as fundamental sensors of the cerebral microcirculation
PROJECT SUMMARY Optimal flow of blood within the brain is ensured by two processes: (1) autoregulation, a collection of intrinsic mechanisms that continuously adjust the microcircu...
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
Project Summary Proposed investigations derive from two on-going R01 GM research programs. The study objectives include the design, synthesis & investigation of synthetic model...
Sleep-dependent modulation of cerebrospinal fluid flow in aging and across genetic risk for Alzheimers disease
Project Abstract Sleep is essential for brain health, and neurodegenerative diseases are associated with substantial sleep disruptions. Disrupted sleep is now thought to not just b...
Genomic and systemic approaches to evolutionary mechanisms
Project Summary The long-term objective of the PI's research program is to discover and understand general principles of evolution in terms of molecular genetic mechanisms and...
Structure-guided and high-throughput engineering of genetically encoded sensors for reactive oxygen species
Modified Project Summary/Abstract SectionElevated levels of reactive oxygen species (ROS) are strongly linked to severe pathological conditions causing cardiomyopathies and neurode...
Development of a tumor-activated IL12 prodrug to treat solid tumors
Project Summary/Abstract: Despite recent advances in cancer immunotherapy, solid tumors remain largely refractory to treatment due to disruption of immune homeostasis by the tumor...
The fibrogenic role of Hippo-Yap signaling following ischemic injury
PROJECT SUMMARY/ABSTRACT End stage heart failure is a common outcome of cardiac injury such as myocardial infarction (MI). Following ischemic injury, prolonged myofibroblast activa...
Personalized Mapping of Affective Lability
PROJECT SUMMARY Affective lability (AL) is a common psychiatric symptom characterized by rapid mood fluctuations. Clinically significant AL often begins in adolescence, is present...
Transgenerational epigenetic inheritance of obesity
PROJECT SUMMARY/ABSTRACT Bisphenol A, BPA, is an endocrine disruptor widely used in consumer products that can be found in the lining of canned goods, plastic water bottles, and me...
Dysregulation of Liver Macrophages in Pancreatic Cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States. Metastasis is the major cause of mortality for pat...
Priming the Rehabilitation Engine: Aerobic Exercise as the Fuel to Spark Behavioral Improvements in Stroke
Stroke is a leading cause of disability in the United States and poses a significant burden to Veterans. The effectiveness of current intervention approaches is limited and many in...
Multiscale investigation of cardiomyopathy-associated mutations in metavinculin
Project Summary/Abstract Familial cardiomyopathies are genetic heart diseases that involve ventricular remodeling and altered cardiac contractility. These diseases are often caused...
CIRCADIAN PATTERN OF REST-ACTIVITY RHYTHMS AND BLOOD PRESSURE AND THE UNDERLYING
Project Summary: Nearly half of US adults present with HTN, one of the strongest risk factors for cardiovascular disease (CVD) and a leading cause of CVD mortality. Blood pressure...
Epigenome editing of the Prader-Willi syndrome imprinted domain with CRISPR/Cas9
Project Summary Prader-Willi Syndrome (PWS) is a complex neurodevelopmental disease that is speculated to affect 1 in ~15,000 live births. Infants affected by PWS initially display...
Role of phosphate availability in lung cancer invasion and bone metastasis
PROJECT SUMMARY Metastatic dissemination is a leading cause of death from cancer with metastasis to bone represents a particularly poor prognosis. Unfortunately, metastasis to bone...
Defining the molecular drivers and modulators of MATR3 proteinopathy implicated in amyotrophic lateral sclerosis and frontotemporal dementia
Project Summary Matrin-3 (MATR3) is a ubiquitous RNA-binding protein which is predicted to be largely disordered. Mutations in MATR3 have been linked to amyotrophic lateral scleros...
Protein Sialylation and De-Sialyation in Cell Surface Glycoprotein Homeostasis and Disease
SUMMARY Protein sialylation is a post-translational modification produced by members of a family of sialyltransferases. We recently discovered that the resulting sialic acid linkag...
Analyzing gene expression in adipose tissue to identify candidate genes at cardiometabolic trait GWAS loci
PROJECT SUMMARY Cardiovascular disease and other related cardiometabolic traits such as obesity and high blood cholesterol pose significant global health burdens. The detection of...