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201,169 grants found
Showing 196,841 – 196,860 of 201,169 grants
Immune Regulatory Roles of Endothelial Cells in Neonatal Heart Regeneration
Project Summary Heart failure (HF) is the long term effect of the mechanical stress and chronic inflammation that occurs following an acute ischemic event in cardiac tissue. Curren...
Mediators Of Arrested Differentiation In Pediatric Rhabdomyosarcoma
Project Summary/Abstract Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Despite rigorous clinical trials the survival for children with high-risk RMS h...
Developing an intervention to improve quality of myocardial infarction care in northern Tanzania
PROJECT SUMMARY Myocardial infarction (MI) is a leading cause of death worldwide. There is a critical need to improve uptake of evidence-based care for MI in resource-limited setti...
Circuits driving spatial coding deficits in epilepsy
Project Summary/Abstract Temporal lobe epilepsy (TLE) is a debilitating disorder that includes pervasive memory impairments that significantly impact quality of life. In rodent mod...
Visual Form Perception Produced by Electrically Stimulating Human Visual Cortex
Project Summary/Abstract Blindness disables millions of people across the world. In most cases, incurable blindness is caused by damage or dysfunction of the eye, retina, or optic...
Mechanisms and Consequences of Tau Internalization and Aggregation in the Central Nervous System
The aggregation of the protein tau occurs in a range of neurodegenerative diseases, including Alzheimer’s Disease1. The presence of tau aggregates, also known as neurofibrillary ta...
Deciphering the molecular control of intratumoral dendritic cells
PROJECT SUMMARY Dendritic cells (DC) have a major influence on tumor immunity. DC depletion abrogates tumor immunity and response to PD1 (αPD1) immunotherapy in many preclinical tu...
The impact of dietary zinc deficiency on innate immunity to lung infection
Zinc deficiency is a major risk factor for pneumonia, and is estimated to contribute to 16% of lower respiratory infections globally by the World Health Organization. Acinetobacter...
A Dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network
Protocol Title: A dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network Summary There is a substa...
Targeting immune suppressive microenvironment in ATC
PROJECT SUMMARY/ABSTRACT Patients with anaplastic thyroid cancer (ATC) have a median survival of 6 months. Chemotherapy in combination with surgery and radiation may modestly exten...
Targeting metabolic remodeling and mitochondrial dysfunction in the diabetic heart
Diabetes mellitus (DM) induces a cardiac muscle disorder known as diabetic cardiomyopathy (DMCM) that progresses to heart failure.A hallmark of DMCM is disrupted metabolism, result...
Engineering Dynamic 3D-Bioprinted Models of Pulmonary Vascular Disease
PROJECT SUMMARY/ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive and incurable disease, characterized by elevated pulmonary blood pressure, remodeling of the pulmona...
Supplement to Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions
PROJECT SUMMARY/ABSTRACT Avoidant/restrictive food intake disorder (ARFID) is identified as a restrictive eating disorder in DSM-5 and is associated with substantial medical morbid...
Analyzing gene expression in adipose tissue to identify candidate genes at cardiometabolic trait GWAS loci
PROJECT SUMMARY Cardiovascular disease and other related cardiometabolic traits such as obesity and high blood cholesterol pose significant global health burdens. The detection of...
Visual Form Perception Produced by Electrically Stimulating Human Visual Cortex
Project Summary/Abstract Blindness disables millions of people across the world. In most cases, incurable blindness is caused by damage or dysfunction of the eye, retina, or optic...
Determining the Platelet Signaling Pathway(s) Critical in Venous Thrombosis Pathogenesis" it might change in the process of editing
Project summary Venous thrombosis (VT) affects close to a million Americans annually. One of the main triggers of VT is flow restriction, which leads to vascular inflammation and i...
Neural Mechanisms of Vibroacoustically Augmented Breath Focused Mindfulness for Dissociative Traumatized People
Dissociation is a multifaceted, transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It is prevalent in traumatized people with posttra...
TMS effects on circuit plasticity and drug seeking in mice.
Project Summary/Abstract Drug addiction is a leading cause of morbidity and mortality in the US. Opioid addiction in particular has become an epidemic with unprecedented overdose f...
Efficient estimation of auditory sensitivity and cognitive status using spoken-digit tests.
Project Summary/Abstract. Untreated age-related hearing loss (ARHL) is the most prevalent cause of reduced quality of life for persons 55 and older in the US. There are 30+ million...