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201,169 grants found
Showing 196,881 – 196,900 of 201,169 grants
IMSD at Stony Brook University: Maximizing Excellence in Research for Graduate Education
Project Summary / Abstract IMSD at Stony Brook University: Maximizing Excellence in Research for Graduate Education The Stony Brook University Initiative for Maximizing Student Dev...
Mechanism of YAP/TAZ crosstalk with Wnt signaling
SUMMARY The Hippo and Wnt signaling pathways are intimately associated with tissue homeostasis and tumorigenesis. However, how these two pathways crosstalk remains elusive and has...
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may...
Optical nanosensor for 3D force sensing in intact tissues of live animals
PROJECT SUMMARY Physical forces are known to impact cell functions in a fundamental way. While the study dates back some 100-years, the scientific interests have significantly incr...
T cell mechanisms of immunotherapy response in pancreatic ductal adenocarcinoma
Project Summary Immune checkpoint inhibitors (ICIs) provide durable clinical responses in about 20% of cancer patients, but have been largely ineffective for non-immunogenic cancer...
Tracing Intratumoral Cellular Heterogeneity using genetic barcoding in small cell lung cancer
PROJECT SUMMARY Tumors are often highly heterogeneous, with a number of functionally different cells existing within a single tumor, giving some cells the ability to initiate new t...
Intelligent in silico antibody library design and optimization for therapeutic use
Antibody discovery technologies have delivered life saving therapies over the past three decades, however, many challenging targets remain undrugged due to limitations of these tec...
CSHL 2021 Brain Barriers Conference
PROJECT SUMMARY The proposed ?Brain Barriers? formerly known as the ?Blood-Brain Barrier (BBB)? meeting, to be held at the Cold Spring Harbor Laboratory (CSHL) from April 7th - 10t...
Sample Barcoding for Ultra High-Throughput Flow Cytometry
Project Summary High-throughput screens are the workhorse of the early drug discovery process.Millions of biochemical or cell-based assays are conducted to test the activity of sma...
AI-driven biomarker analysis of intact whole brains imaged at micron and sub-micron resolution
Abstract.Whole-organ 3D immunohistochemistry is revolutionizing the field of neuroscience, enabling unprecedented insight into the distribution of neural cells and neurological mar...
Identifying Patient Subgroups That Are Most Likely To Benefit From Medications Used To Treat Alcohol Use Disorder
PROJECT SUMMARY/ABSTRACT The objective of this K01 award is to provide Dr.Joshua Wallach, an Assistant Professor of Epidemiology at the Yale School of Public Health, with the prote...
Genomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic Ancestry
ABSTRACT Alzheimer disease (AD) is the leading cause of dementia in older adults and occurs in all ethnic and racial groups. Genetic studies of AD have mostly been performed in non...
Improving sleep in gynecologic cancer survivors
PROJECT SUMMARY Sleep disturbance is one of the primary complaints of gynecologic cancer survivors, with more than 80% of survivors reporting sleep difficulties. Sleep disturbance...
Cancer misinformation on social media and its correction
Project Summary The overarching goal of this study is to measure the prevalence of cancer misinformation on social media and understand the mechanisms that underlies its spread.Bel...
Immunization against Pf bacteriophage in Pseudomonas aeruginosa infection
Project Summary Pseudomonas aeruginosa (Pa) is a deadly bacteria that is strongly associated with wound infections, particularly in the setting of immunocompromised hosts such as d...
The Impact of Thrombosis and Antithrombotic Therapy on Peripheral Artery Disease
The applicant, Aaron W.Aday, MD, is an Instructor of Medicine in the Division of Cardiovascular Medicine at Vanderbilt University Medical Center.The applicant's goal is to bec...
Diversification of cell types in the Drosophila retina - Resubmission - 1
Summary The development of a complex organ such as the eye involves the specification of multiple distinct cell types and the integration of their functions.In Drosophila, the ligh...
A Novel Approach to Restore Sight after Corneal Chemical Injury
Abstract Chemical burns to the eye are potentially blinding ocular injuries and constitute an ocular emergency requiring immediate assessment and initiation of treatment. They also...
Slow cycling cell RNA based T cell therapy to prevent recurrence in GBM
PROJECT SUMMARY AND ABSTRACT Conventional cancer treatments target fast-cycling cells, however slowly dividing populations tend to be spared recapitulating the tumor via their self...
The Impact of Aging on the Neural and Behavioral Bases of Empathy
Project Summary/Abstract: Research Project (C) By 2060, adults 65-years of age and older are predicted to make up 24% of the U.S. population. Therefore, factors that impact older a...