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201,169 grants found
Showing 196,901 – 196,920 of 201,169 grants
Engineered Biomaterial for Endoscopic Treatment of Airway Fibrosis
PROJECT SUMMARY In this proposal, our primary goal is to explore the optimization of a biomaterial to prevent the recurrence of fibrosis and promote regeneration of mucosal epithel...
Sequence-universal high-frequency prospective MRI motion correction with navigators
Project Summary/Abstract Motion during magnetic resonance imaging (MRI) is estimated to cost hospitals approximately $115,000 per scanner per year, which implies that the annual co...
Targeting B7-H3 in ovarian cancer
ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the...
Molecular Mechanism of NLRP1 and CARD8 Inflammasome Regulation by DPP9
Abstract The inflammatory response provides an absolutely essential host defense mechanism that, if perturbed, can itself cause a large number of human diseases.Collectively, innat...
Blood-brain-barrier and white matter mechanisms underlying dementia
Abstract White matter (WM) damage has increasingly been recognized as an important contributing factor to neurodegeneration and dementia, however, little is known of the specific m...
Intravenous ivermectin for sepsis
SUMMARY Sepsis is caused by severe infection, which results in systemic disease. Sepsis remains the leading cause of morbidity and mortality in critically ill patients.One reason f...
A Novel LIGHT/TL1A Bispecific Antibody for the Treatment of Fibrotic Diseases
Project Summary Our objective is to produce a bispecific antibody, VTC-890, capable of binding two proinflammatory cytokines, LIGHT (TNFSF14) and TL1A (TNFSF15), for the treatment...
CSHL Network Biology Conference
PROJECT SUMMARY This proposal seeks support for the conference on Network Biology, to take place March/April 2021 to 2025, at the Cold Spring Harbor Laboratory (CSHL).This meeting,...
Development of a selective PI3K-Akt-activating neurotrophic small molecule drug, MT-002, for the healing of corneal wounds in Neurotrophic Keratitis.
Calista is developing topical MT-002, a selective PI3K-Akt activator that safely restores normal wound healing in a clinically predictive animal model of Neurotrophic Keratitis (NK...
Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling
Project Summary Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer mortality in the United States.HCC is preventable, and it disproportionately affects migrants...
Multiscale investigation of cardiomyopathy-associated mutations in metavinculin
Project Summary/Abstract Familial cardiomyopathies are genetic heart diseases that involve ventricular remodeling and altered cardiac contractility.These diseases are often caused...
Characterization of ILEI/LIFR Axis-induced Intracellular Signaling
Project Summary Our lab has previously identified a mechanism of transforming growth factor beta (TGF?)-mediated epithelial-to-mesenchymal transition (EMT) in murine mammary epithe...
Engineering Dynamic 3D-Bioprinted Models of Pulmonary Vascular Disease
PROJECT SUMMARY/ABSTRACT Pulmonary arterial hypertension (PAH) is a progressive and incurable disease, characterized by elevated pulmonary blood pressure, remodeling of the pulmona...
Mitochondria targeting for Alzheimer's Disease
PROJECT SUMMARY OF PARENT AWARD Decreased energy metabolism is an invariant feature of the brains of Alzheimer's disease (AD) patients, yet the specific use of pharmacologic s...
High Resolution Characterization of Bacterial Epigenomes and Microbiome
PROJECT SUMMARY/ABSTRACT My long term goal is to comprehensively understand the diversity, heterogeneity and functions of bacterial epigenomes both in terms of basic science and bi...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis
Abstract The objectives of this proposal are two-fold and include the development and conceptual advancement of contra- thermodynamic catalysis and fluorine sculpting.The realizati...
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
Project Summary/Abstract: This equipment supplement project proposal seeks funds to purchase a Cold-Spray Ionization Mass Spectrometer to carry out CSI-MS experiments, a powerful a...
Structure, Mechanism and Interactions of Type IA Topoisomerases
Project Summary PI: Yuk-Ching Tse-Dinh This equipment supplement application requests funds to purchase an AKTA FPLC protein purification system for the large scale purification of...
CHEMISTRY CENTER FOR COMBATING ANTIBIOTIC-RESISTANT BACTERIA (CC4CARB)
The Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) will synthesize and deliver rationally designed compound libraries to the scientific community to facilit...