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201,169 grants found
Showing 196,961 – 196,980 of 201,169 grants
SBIR Phase II: Next-Generation Capillary Electrophoresis with Mass Spectrometry for Biopharmaceutical and Biomedical Applications
The broader impact of this Small Business Innovation Research (SBIR) Phase II project will be the development of a new instrument for biological research, biomedical research, and...
RAPID: Dual-Doppler Analysis of the Boundary Layer in Category-4 Hurricane Laura
Hurricane Laura made landfall in southwestern Louisiana in August 2020 as a high-end Category 4 storm. The landfall represented a unique opportunity to make scientific measurements...
CAREER: Molecular level consequences of mRNA modification
Cells face the daunting challenge of accurately synthesizing the correct number of proteins at the right time. Messenger ribonucleic acids (mRNAs) serve as blueprints for protein s...
RII Track-4: Collaborative partnerships at the cusp of wildlife ecology and molecular biology
This Research Infrastructure Improvement RII Track-4 grant will examine how the migratory wildlife of Yellowstone National Park adjust their diets in response to seasonal change. S...
Signaling from sarcomere to mitochondria: a new paradigm for optimal muscle performance
Muscle function allows an animal to move, to maintain posture, and to perform heart pumping. Most of the energy required for muscle activity, stored and released from the small che...
CAREER: In Operando Investigation of Laser Powder-fed Directed Energy Deposition: Process Physics, Microstructure Evolution, and Mechanical Properties
The disruptive innovation of additive manufacturing relies on its ability of mass customization of complex-shaped products that are impossible or difficult to make by conventional...
SBIR Phase I: Nanoremediation of oily waste waters from spills and discharges
The broader impacts of this Small Business Innovation Research (SBIR) Phase I project address oil pollution in Alaskan waters by reducing costs associated with oil cleanup projects...
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and inc...
Access, Quality and Equity of Anticoagulants in Veterans with Atrial Fibrillation
Background. Atrial fibrillation (AF) is a common cardiac arrhythmia, affecting up to 1 million Veterans. AF increases the risk of stroke by 5-fold and is associated with higher rat...
Peer Coaching for Physical Activity Promotion among Breast Cancer Survivors: Adapting an Efficacious Intervention to Prepare for Implementation
Interventions promoting physical activity among cancer survivors improve their functioning, reduce fatigue and offer other benefits in cancer recovery and risk reduction for future...
Fortilin, CTNNA3, and the Heart
Project Summary The main goal of this grant proposal titled “Fortilin, CTNNA3, and the Heart” is to test the central hypothesis that the inability of the failing heart to maintain...
Expansion and validation of novel mobile app for guiding home modifications for aging in place
PROJECT SUMMARY In this Phase II SBIR, HomesRenewed Ventures, LLC (HRV Washington, DC) will build on our previous efforts to expand and validate an interactive mobile application (...
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brain
Project Summary Although functional gastrointestinal (GI) disorders (FGIDs) are the most common causes of bowel dysfunction worldwide, many patients are inadequately treated becaus...
Development of selective HDAC6 inhibitors to improve cancer immunotherapy
Project Summary The median survival for metastatic melanoma is approximately 8–16 months, and few therapies offer a significant improvement in overall survival. However, immunother...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development
ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal an...
Immunotherapy for Ocular Surface Diseases
ABSTRACT We have discovered a new mechanism for inflammation on the ocular surface. First, we discovered the presence of neutrophil extracellular traps (NETs) on the ocular surface...
Development of Poly (pro-curcumin) Polymer Coatings to Improve Cortical Electrode Biocompatibility
This application aims to create innovative polymer coatings to improve intracortical microelectrode biocompatibility. Following intracortical microelectrode implantation, an inflam...
Abbreviated Non-Contrast-Enhanced MRI for Breast Cancer Screening
Project Abstract Overview: In 2020, over 276,000 women will be diagnosed with invasive breast cancer, and over 48,000 will die from it. The ultimate goal of this project is to prov...