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201,169 grants found
Showing 196,981 – 197,000 of 201,169 grants
Elucidating the role of NK cells in Lewy body diseases
PROJECT SUMMARY/ABSTRACT Lewy body diseases including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy are characterized by the accumulation of...
IMSD at Rutgers - New Brunswick
Abstract/Summary This T32 IMSD proposal aims to increase the pool of PhD scientists from underrepresented (UR) backgrounds who contribute and have a significant impact on the healt...
Targeting immunosuppressive adenosine in patients with metastatic non-small cell lung cancer
SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed the management of patients with metastatic non-small cell lung cancer (NSCLC). Unfortunately, over 50% of pati...
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
The Effect of Screening and Referral for Social Determinants of Health on Veterans' Outcomes
Background: Despite medical advances, up to 70% of health outcomes are due to social determinants of health (SDoH) - the conditions in which people live and work that shape whether...
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. This large affected population and the severe...
Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate models
ABSTRACT The increasing number of bubonic/pneumonic plague cases globally (2010-2018), including the U.S., with a ~18% case fatality rate may reflect climate changes and a rodent c...
Enabling nationwide AD PET imaging to support most efficient clinical trials by adoption of radically simplified and standardized quality control in commercial production of AD PET tracers.
Most recent advances in the management of AD call for extensive use of Positron Emission Tomography (PET)imaging in order to maximize patient benefits, as reflected in Draft NIA-AA...
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
ABSTRACT Recently there has been compelling evidence that inflammatory bowel disease (IBD) subjects, both Crohn's disease (CD) and Ulcerative Colitis (UC), commonly have disru...
Language Development and Social Interaction in Children with Hearing Loss
Project SummaryThis project uses objectively measured, longitudinal data to capture the vocal interactions of children with hearing loss in order to understand everyday factors tha...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
Discovering the role of YES1 in triple negative breast cancer
PROJECT SUMMARY/ABSTRACT SRC Family Kinases (SFKs) are a group of 9 non-receptor tyrosine kinases that mediate the effects of many extracellular and intracellular signaling pathway...
NCI Diversity Supplement: Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
ABSTRACT A separate Abstract is not requested. This is an NCI Diversity Supplement to Dr. Juan Fueyo-Margareto’s NCI grant, R01 CA256006, titled, “Glioma therapy with oncolytic ade...
Identifying low dose measurement error corrected effects of multiple pollutants using causal modeling
The Global Burden of Disease estimates that ambient air pollution is responsible for over 4 million deaths per year, yet regulators in the US, EU, India, and China have been reluct...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Evolutionary adaptation and spatial organization of signaling in the Mitotic Exit Network
Project Summary Sensing and processing information through signaling cascades is an essential part of cellular life. A few signaling cascades such as the MAP kinase and Hippo pathw...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually. Consequences of postpartum depress...
Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding
ABSTRACT The proteostasis network relies on numerous feedback mechanisms to strike a balance between the rates of protein synthesis and degradation, which is crucial for the mainte...
Molecular mechanisms of the mitochondrial permeability transition
The overarching goal of my research program is to identify and characterize molecular mechanisms responsible for stress-induced permeabilization of the mitochondrial inner membrane...
Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being
Advancing Psychosocial & Biobehavioral Approaches to Improving Emotional Well-Being PROJECT SUMMARY/ABSTRACT Given rising levels of global stress, exacerbated by the pandemic,...