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201,169 grants found
Showing 197,001 – 197,020 of 201,169 grants
Mitochondrial lateral transfer during metastasis
Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that mac...
Ethnoracial Impact on Blood-Based Biomarker Detection of Alzheimer's in Primary Care Patients
Project Summary/Abstract If no preventative measures are developed, the number of individuals suffering from Alzheimer’s Disease (AD) is expected to triple by 2050; many of whom wi...
MIRA supplement
Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT SUMMARY What if healthcare providers were equipped with biocompatible, biodegradable, robus...
Network For Emotional Wellbeing And Brain Aging (NEW Brain Aging)
Project summary: Early evidence indicates an association between emotional (eudaimonic and hedonic) well- being (EWB) and underlying brain processes, and that those processes chang...
Protein Networks as Synergistic Drivers of Membrane Remodeling
Summary Abstract: Protein Networks as Synergistic Drivers of Membrane Remodeling Membrane curvature is required for many cellular processes, from assembly of highly curved traffick...
Electroencephalographic biomarkers of response to vibroacoustically-augmented breath-focused mindfulness
Dissociation is a transdiagnostic, and disabling phenomenon that involves detachment from the self or surroundings. It occurs in the context of many trauma and stress-related disor...
Sex differences in cholinergic regulation of nicotinic acetylcholine receptor modulation of local nucleus accumbens circuitry underlying motivation
Project Summary/Abstract Candidate: My long term goal is to become an independent investigator running an interdisciplinary and collaborative research team to understand the mechan...
Impact of Loss-of-function NADPH Oxidase Variants on B-Cell Activation in SLE
PROJECT ABSTRACT Genome-wide association studies (GWAS) have identified immune pathways linked to the pathogenesis of systemic lupus erythematosus (SLE). However, despite these ins...
Characterizing the content of bilingual language in preschoolers with HL
Project Summary This Administrative Supplement will support post-baccalaureate researcher, Gabriela Gutierrez, to receive research training through her mentored leadership of a pro...
K-B focusing mirror system and monochromator upgrade for the BioCAT Beamline 18ID at the Advanced Photon Source.
The purpose of this administrative supplement request is to allow us to procure a “K-B focusing mirror system and monochromator upgrade for the BioCAT Beamline 18ID at the Advanced...
Exploiting Unconventional Building Blocks in Chemical Synthesis
Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, metho...
Fluorescent nucleosides, nucleotides and oligonucleotides
PROJECT SUMMARY Nucleic acids and their building blocks play central roles in all cellular events and, as such, have immense impact on the emergence of diseases and, in turn, on hu...
Structural Studies of Macromolecular Assemblies Using Cryo-EM
Project Summary/Abstract The main objective of the proposed studies is the elucidation of fundamental processes of translation, translational regulation and translational quality c...
Methods For Evolutionary Genomics Analysis
Summary The parent R35 research program aims to develop innovative methods and tools for the comparative analysis of molecular sequences. The focus is on creating machine-learning...
Molecular mechanisms of the mitochondrial permeability transition
Research Summary The overarching goal of my research program is to identify and characterize molecular mechanisms responsible for stress-induced permeabilization of the mitochondri...
Mitotic transmission of acentric chromosome fragments
The goal of this proposal is to elucidate the molecular and cellular basis of a newly discovered diverse set of adaptive mechanisms that maintain the integrity of the genome during...
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension
Project Summary/Abstract Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by an obliterative vasculopathy involving distal pulmonary a...
Exploring the Effects of Cannabinoids on Alcohol Consumption and the Microbiota-Gut-Brain Axis
Summary Increasingly liberal cannabis policies in the U.S. have been associated with both “replacement”, whereby cannabis is substituted for alcohol, thus decreasing alcohol use, a...
Using a Data-driven Approach to Improve Persistence of Academically Talented STEM Students with High Unmet Financial Need
This project will contribute to the national need for well-educated scientists, mathematicians, engineers, and technicians by supporting the retention and graduation of high-achiev...
REU Site Mystic Aquarium: Collaborative Research: Plankton to Whales: Consequences of Global Change within Marine Ecosystems
This REU Site award to Mystic Aquarium (MA), located in Mystic, CT, will support the training of 10 students annually for 10 weeks during the summers of 2020 - 2022. Research is co...