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201,169 grants found
Showing 197,141 – 197,160 of 201,169 grants
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Integrated proteomic and metabolomics analysis of thrombotic myocardial infarction
Project Summary / Abstract: Acute myocardial infarction (MI) is defined as myocardial ischemia, the inadequate supply of blood to heart muscle, followed by myocardial cell death.Mu...
Deciphering the molecular mechanisms of TNT formation and function using a multi-omic approach
Our research is focused on the role of tunneling nanotubes (TNTs)?a novel mechanism of functional connectivity between cells?in the spreading of viruses, misfolded protein aggregat...
Training in Implementation Science Research and Methods
Abstract Implementation science is the domain of scholarship that studies methods to facilitate the spread and adoption of evidence-based practices into real-world settings. The fi...
Training Program in Resuscitation Science
Abstract We aim to provide advanced multidisciplinary research training in the emerging field of resuscitation science to physician- and PhD-scientists to jump-start their progress...
Alzheimer's disease-replicated brain microphysiological system to model AD physiopathology and its influenceon gliovasculature and immune system
Abstract Two hallmarks of Alzheimers Disease are accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles, which disrupt brain function.Recent eviden...
Access, Quality and Equity of Anticoagulants in Veterans with Atrial Fibrillation
Background. Atrial fibrillation (AF) is a common cardiac arrhythmia, affecting up to 1 million Veterans. AF increases the risk of stroke by 5-fold and is associated with higher rat...
Tumor Metabolism and the Microenvironment
ABSTRACT Support is requested for a Keystone Symposia conference entitled Tumor Metabolism and the Microenvironment, organized by Drs. Erik A. Sahai, Alec Kimmelman and Johanna A....
On differentiating selective and neutral evolutionary processes
ABSTRACT At the founding of population genetics in the early 20th century, S. Wright and R.A.Fisher developed much of the mathematical and conceptual framework underlying the study...
Nuclear Organization and Function
PROJECT SUMMARY. Proper regulation of gene expression is essential for cell differentiation and homeostasis.Most of our understanding of the mechanisms that control the transcripti...
IMSD at Wayne State University
The mission of Wayne State University (WSU), to create and advance knowledge, prepare a diverse student body to thrive, and positively impact local and global communities, is very...
IMSD at Rutgers - New Brunswick
Abstract/Summary This T32 IMSD proposal aims to increase the pool of PhD scientists from underrepresented (UR) backgrounds who contribute and have a significant impact on the healt...
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq
Project Summary: Salt-sensitive hypertension is an independent predictor of death due to cardiovascular disease (CVD), but the mechanisms are poorly understood.Most of the research...
Targeting vulnerabilities of PPM1D-mutant gliomas
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments.We and others have observed up to 15% of all DMGs to h...
Embryonic vascular stem-progenitors for treatment of ischemic retinopathies
Branch vein occlusion (BVO) and diabetic retinopathy (DR) are major causes of new onset blindness in the US.These vascular disorders result in acellular capillaries secondary to is...
Characterizing Human RPE Cell Proliferation to Advance Endogenous Regeneration
Project Summary / Abstract Decades of study have demonstrated that adult human retinal pigment epithelium (RPE) cells have strong proliferative capacity in vitro, which indicates t...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7.Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers,...
Elucidating the role of NK cells in Lewy body diseases
PROJECT SUMMARY/ABSTRACT Lewy body diseases including Parkinson's disease (PD), Lewy body dementia (LBD), and multiple system atrophy are characterized by the accumulation of...
Optical analogs to MRI contrast agents for surgical guidance of brain tumor resection
ABSTRACT Surgical resection is a fixture in the treatment of intracranial tumors, and there is mounting data indicating that overall and progression-free survival improve for gross...