Browse All Grants
201,169 grants found
Showing 197,161 – 197,180 of 201,169 grants
Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism
SUMMARY Investigating Syndecan-1 in Hepcidin Regulation and Iron Metabolism. Iron is an essential trace mineral, involved in many vital cellular and organismal functions.Organismal...
Function of RUNX1 in diverse Down syndrome tissues
Summary We seek to decipher the contribution of RUNX1 to the phenotypes seen in individuals with Down syndrome.RUNX1 is a chromosome 21 encoded transcription factor involved in blo...
A hybrid effectiveness-implementation trial of a school based executive function treatment for transition age youth with autism
PROJECT SUMMARY The proposed study is highly relevant to the 2017 Interagency Autism Coordinating Committee priorities to improve transition to adulthood in autism spectrum disorde...
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial Hypertension
PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a disease of the pulmonary arterial vasculature and its remodeling, in which patient mortality is significantly associated...
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill Children
SUMMARY Lower respiratory tract infections (LRTI) lead to more deaths each year in children than any other infectious disease category.Despite this, the underlying microbial pathog...
Delineating developmental programs driving tumorigenesis in triple-negative breast cancer
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is the deadliest and 2nd most common subtype of breast cancer in the United States.Although promising new drugs based on PARP i...
Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
SUMMARY / ABSTRACT With current treatment options, the five-year survival rate of patients with glioblastoma (GBM) is only 5%. Oncolytic viruses are promising treatments against so...
A large animal model to elucidate the role of LGR5 stem cells in cancer
Project Summary In the United States, colorectal cancer (CRC) is the 3rd leading cause of cancer death among women and men combined, with of 1 in 20 people being diagnosed with CRC...
Artificial intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Keratoplasty (AUTO-DALK)
PROJECT SUMMARY Contemporary ocular surgeries are performed by skilled surgeons through operating microscopes, utilizing freehand techniques and manually operated precision micro-i...
Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression
Project Summary Carriers of the apolipoprotein E (APOE) ?4 gene are at a significantly increased risk for developing Alzheimer?s disease (AD). Although numerous theories have been...
A Dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network
There is a substantial body of literature to support that biological and prosthetic complications occur which may interfere with the health of the peri-implant tissues, the functio...
The Role of the Tau in Homeostatic Scaling and Mechanisms of Alzheimer's Disease
Project Summary Little is unknown about the mechanisms involved in the regulation of neuronal network activity by the microtubule associated protein tau, a key pathogenic protein i...
Elucidating the causal associations underlying Alzheimer's disease
Project Summary Alzheimer?s disease (AD) is a global crisis facing the aging population and society as a whole.With the number of people living with AD predicted to rise dramatical...
Myeloid TLR4 epigenetic regulation and signaling in accelerating venous thrombus resolution
PROJECT ABSTRACT This proposal describes the 5-year training program for development of a research career in vascular biology, with focus on thrombosis. The candidate, Dr.Andrea Ob...
Developing an intervention to improve quality of myocardial infarction care in northern Tanzania
PROJECT SUMMARY Myocardial infarction (MI) is a leading cause of death worldwide. There is a critical need to improve uptake of evidence-based care for MI in resource-limited setti...
Causal machine learning methods for studying the effects of environmental exposures on childhood cancer using natural experiments
Project Summary: My goal is to build an independent research program in the development of causal inference methods for investigating environmental causes of childhood cancer.This...
Understanding the regulation of neuron cell number and arbor size
PROJECT SUMMARY/ABSTRACT How the brain generates the correct number of neurons and how these neurons determine the size of their arbors to innervate the receptor field is a critica...
Intervertebral Disc Mechanics with Functional GRASP-MRI
PROJECT SUMMARY Low back pain (LBP) is a major clinical and socioeconomic global health burden. In fact, LBP affects nearly all of us at least once in our lives, and in ~20% the co...
A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and Mechanisms
ABSTRACT As one of the most common pregnancy complications, nearly 600,000 women in the United States suffer from postpartum depression annually.Consequences of postpartum depressi...
Development of High-Performance Multi-Contrast Echo Planar Imaging
Quantitative T1 MRI of the brain provides valuable insight into the health status of brain tissue.To estimate T1, an image slice is acquired with multiple inversion time (TI) value...