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201,169 grants found
Showing 197,181 – 197,200 of 201,169 grants
Immune Mechanisms Regulating Cardiac Remodeling
Summary Cardiovascular disease is the number cause of death in the United States. Most cardiovascular diseases are associated with an increase in myocardial mass or cardiac hypertr...
The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions
PROJECT SUMMARY/ABSTRACT Avoidant/restrictive food intake disorder (ARFID) is identified as a restrictive eating disorder in DSM-5 and is associated with substantial medical morbid...
Molecular Mechanisms of Co-Transcriptional Ribonucleoprotein Assembly
PROJECT SUMMARY RNAs are integral components of molecular machines that carry out all essential processes in gene expression.To expand the functional landscape of these molecular m...
Epstein-Barr Virus nuclear antigen leader protein in transcription regulation
Abstract: Epstein-Barr virus (EBV) associated diseases remain a huge burden in human health.As an orally transmitted pathogen, EBV infection causes infectious mononucleosis and ~20...
In Vitro Toxicity Testing at Massive Scale in Diverse Primary Human Cells
PROJECT SUMMARY?Coral Genomics is combining whole genome sequencing and RNA profiling in cell- based functional assays to predict human variation in the metabolism and toxicity of...
A New Strategy to Increase Proteotoxic Cell Death in Hepatocellular Carcinoma
Inhibitors of the ubiquitin proteasome system (UPS, the major pathway that degrades unfolded proteins) increase proteotoxic stress and have clinical success for multiple myeloma bu...
The brain cholesterol interactome
Abstract Both serum cholesterol levels and the cholesterol carrying protein ApoE have been implicated in the development of Alzheimer?s disease. Despite intensive research, there i...
Arsenic's effects on the intestinal stem cell niche
7.Project Summary/Abstract Arsenic is a contaminant found in drinking water and food, resulting in the exposure of millions of people to concentrations above the current US EPA and...
Role of CD36 and diet-derived fatty acids in breast cancer
Abstract Fat is one of the three main nutrients, along with carbohydrate and protein.Fats are important sources of fatty acids (FAs), which are lipids that play a pivotal role in m...
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone.This large affected population and the severe...
Role of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humans
SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and inc...
National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource
PROJECT SUMMARY/ABSTRACT This project aims to disseminate validated technologies and resources of the National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego to...
Role of Surfactant Protein-C Mutation and Ozone Exposure in the Exacerbation of Pulmonary Fibrosis
Project Summary/Abstract: Pulmonary fibrosis (PF) is a rare degenerative disease characterized by progressive lung stiffening, resulting in death within 3-5-years of diagnosis.Comp...
Novel approaches for relating genetic variation in endogenous retroviruses to function and disease
PROJECT SUMMARY/ABSTRACT Genome-wide association studies (GWAS) for complex traits have often revealed a significant proportion of risk attributed to the non-coding genome.This has...
AIDS-related HSV-1 retinal necrosis: Innate immunity and virus spread
Program Director/Principal Investigator (Last, First, Middle): Dix, Richard D Project Summary AIDS patients can develop a variant of acute retinal necrosis (ARN) designated progres...
Maintenance of synapses during adulthood in Drosophila
PROJECT SUMMARY The goal of this proposal is to identify genes that regulate an age-dependent change in active zones (AZs) that causes an age-dependent decline in neuron function....
Development of enthesopathy in the mouse model of X-linked hypophosphatemia
X-linked hypophosphatemia (XLH) is the most common form of inheritable rickets characterized by mutations in PHEX. These mutations result in elevated serum levels of FGF23, which l...
Describing the Epigenetic Mechanisms in Control of Hematopoietic Development and Rapid Inflammatory Responses
Project Summary Complex organisms face daunting ?epigenetic challenges?. How is a single genome interpreted to instruct over one thousand distinct cell fates? How do extracellular...
Describing the Epigenetic Mechanisms in Control of Hematopoietic Development and Rapid Inflammatory Responses
Project Summary Complex organisms face daunting “epigenetic challenges”. How is a single genome interpreted to instruct over one thousand distinct cell fates? How do extracellular...
Describing the Epigenetic Mechanisms in Control of Hematopoietic Development and Rapid Inflammatory Responses
Project Summary Complex organisms face daunting “epigenetic challenges”. How is a single genome interpreted to instruct over one thousand distinct cell fates? How do extracellular...