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201,169 grants found
Showing 197,201 – 197,220 of 201,169 grants
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of many...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of many...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of many...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Environmental genotoxin exposure is responsible for 80-90% of the risk of developing cancer. Indeed, Whole Genome Sequencing studies show that human cancers carry m...
Urinary DNA Adductomics for the Assessment of Exposure to Cancer Risk Factors
PROJECT SUMMARY Exposure to environmental, and endogenous, agents can induce DNA damage, and the consequential genomic instability plays a critical role in the pathogenesis of many...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY/ABSTRACT Over the last twenty years, an increasing number of agricultural communities have faced an apparently new, unexplained, and fatal kidney disease, known as...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY The proposed diversity supplement supports post-doctoral research training for Dr. Marimar Contreras-Nieves, MD, MS candidate. Dr. Contreras-Nieves aims to develop...
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicatin...
Biomolecular Markers for Safe Minimization of Immunosuppression
We seek additional funds for research responsive to the SARS-CoV-2/COVID-19 outbreak that is in scope ofour ongoing grant R37AI051652 “Biomolecular Markers for Safe Minimization of...
Cystitis-induced bladder dysfunction and pain
Project Summary/Abstract Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) is a chronic pelvic pain disorder with at least one urinary symptom and the perception that the pain...
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
Obesity is a major co-morbidity factor in diabetes, cancer, cardiovascular, neurological and other diseases.Recently, a new group of human genes was linked to obesity, the genes en...
Chronic kidney disease of unknown etiology: applying a multidisciplinary approach to investigate the world's most common tubulointerstitial kidney disease
PROJECT SUMMARY/ABSTRACT Over the last twenty years, an increasing number of agricultural communities have faced an apparently new, unexplained, and fatal kidney disease, known as...
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a debilitating disease in which occlusion of the peripheral arteries of the lung causes elevation in pulmonary vascular resistance that cul...
SPMs, linoleic acid, and antibody levels in obesity
PROJECT SUMMARY Numerous studies have defined how obesity impairs chronic inflammation.In contrast, far less is known about how obesity impairs humoral immunity, which is responsib...
Human anti-viral immune responses in tissues and circulation
Program Summary Studies of human immune responses to viruses and other pathogens have focused, by necessity, on sampling of peripheral blood; however, innate and adaptive immune re...
IMPACC convalescent data collection, including Patient Reported Outcomes (PROs) and home visit sampling
IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC): Clinical and Data Coordinating Center (CDCC) Project summary In December 2019, a cluster of respiratory illness in Wuhan...
Biomolecular Markers for Safe Minimization of Immunosuppression
We seek additional funds for research responsive to the SARS-CoV-2/COVID-19 outbreak that is in scope of our ongoing grant R37AI051652 ?Biomolecular Markers for Safe Minimization o...
A rapid, automated system for bacteria profiling of intra-abdominal infections
Project Summary New diagnostic tools capable of rapidly identifying and quantifying bacteria within intra-abdominal infections are needed to help clinicians select appropriate anti...
Contribution of c-Maf to regulatory B cells and antibody-secreting cells
PROJECT SUMMARY Regulatory B cells are involved in many pathophysiological processes, such as promoting tolerance in autoimmunity and organ transplantation, but also reducing immun...
Exploring the heterogeneity of the vaccine-elicited T cell response by scRNAseq
PROJECT SUMMARY Clinically relevant cellular responses to either experimental or FDA approved vaccine adjuvant formulations have been difficult to generate and/or detect.Given the...