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201,169 grants found
Showing 197,241 – 197,260 of 201,169 grants
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affect
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) afflicts millions of individuals and their families each year. AUD is frequently comorbid with anxiety and depression, indicatin...
A rapid, automated system for bacteria profiling of intra-abdominal infections
Project Summary New diagnostic tools capable of rapidly identifying and quantifying bacteria within intra-abdominal infections are needed to help clinicians select appropriate anti...
The role of regulator of G protein signaling Gbeta5-R7 in neuronal control of body weight
Obesity is a major co-morbidity factor in diabetes, cancer, cardiovascular, neurological and other diseases. Recently, a new group of human genes was linked to obesity, the genes e...
Cystitis-induced bladder dysfunction and pain
Project Summary/Abstract Bladder Pain Syndrome (BPS)/Interstitial Cystitis (IC) is a chronic pelvic pain disorder with at least one urinary symptom and the perception that the pain...
High Shear Stress Alters Gene Regulation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a debilitating disease in which occlusion of the peripheral arteries of the lung causes elevation in pulmonary vascular resistance that cul...
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review of...
Dynamics of co-transcriptional riboswitch folding through single-molecule microscopy
Project Abstract and Summary: RNA elements known as riboswitches are critical for proper genome expression and maintenance in many prokaryotes.Riboswitches are generally found upst...
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review of...
Dynamics of co-transcriptional riboswitch folding through single-molecule microscopy
Project Abstract and Summary: RNA elements known as riboswitches are critical for proper genome expression and maintenance in many prokaryotes. Riboswitches are generally found ups...
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review of...
Fluid shear stress mechanotransduction at endothelial cell-cell junctions
Summary of the funded parent grant The goal of our project “Fluid shear stress mechanotransduction at endothelial cell-cell junctions” is to elucidate mechanisms by which vascular...
Primed to (re)act: Can changes in procedural language prevent adverse events between police and minority male youth?
PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review of...
Mapping & quantifying lymphatic drainage of the arm's alternate pathway
Project Summary/Abstract Breast Cancer Related Lymphedema affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness,...
Remodeled airway irritant reflexes as a cause of serious cardiovascular events
Air pollutants/irritants evoke dangerous sympathoexcitatory reflexes in individuals with cardiovascular disease (CVD) but evoke sympathoinhibitory reflexes in healthy subjects. How...
New BioCascade System for Investigating the Airborne Transmission Modes of Respiratory Viruses
Project Summary While knowledge of the transmission modes for respiratory pathogenic viruses is critical, understanding their transmission mechanisms is hampered by existing sampli...
FAST-FNA immune cell profiling in HNSCC
Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue.Curr...
MCSP TORFP NO. NIH-NINDS-21-01: FLORIO (ANAGIN) - BASE EC (STROKE)
The scope of this MCSP task order shall be medicinal chemistry services under Performance Area 2: Medicinal Chemistry Support in support of preclinical drug discovery efforts suppo...
Mapping & quantifying lymphatic drainage of the arm's alternate pathway
Project Summary/Abstract Breast Cancer Related Lymphedema affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness,...
Remodeled airway irritant reflexes as a cause of serious cardiovascular events
Air pollutants/irritants evoke dangerous sympathoexcitatory reflexes in individuals with cardiovascular disease (CVD) but evoke sympathoinhibitory reflexes in healthy subjects. How...
FAST-FNA immune cell profiling in HNSCC
Currently, the single best predictive biomarker of response to anti-PD1 monotherapy is PD-L1 expression as assessed by immunohistochemical staining of archived or fresh tissue. Cur...