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201,169 grants found
Showing 197,281 – 197,300 of 201,169 grants
Core Fucosylation of N-linked Glycans as a Regulator of CD8+ T cell Activation and Function
PROJECT SUMMARY/ABSTRACT Post-translational carbohydrate modifications are important mediators of several cellular processes including protein turnover, cell adhesion, signal trans...
Exploring the Limits of Ribosome Mediated Polymerizations for Expanding the Genetic Code
PROJECT SUMMARY Recombinant protein production (RPP) has become a powerful tool for producing life-saving therapeutics such as insulin, monoclonal antibodies, and other critical bi...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION:It is truly remarkable that our bodies turn over on average about one million cells every second of life....
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION:It is truly remarkable that our bodies turn over on average about one million cells every second of life....
Imaging sodium and lymphatics in lymphedema
The overall goal of this work is to investigate lymphatic vascular mechanisms of tissue sodium handling using novel, noninvasive imaging tools sensitive to sodium and lymphatics in...
Solute carrier proteins in efferocytosis and inflammation
Abstract: SOLUTE CARRIER (SLC) PROTEINS IN EFFEROCYTOSIS AND INFLAMMATION:It is truly remarkable that our bodies turn over on average about one million cells every second of life....
Imaging sodium and lymphatics in lymphedema
The overall goal of this work is to investigate lymphatic vascular mechanisms of tissue sodium handling using novel, noninvasive imaging tools sensitive to sodium and lymphatics in...
Epigenetic Determinants and Mechanisms Influencing Genital Chlamydia trachomatis Reinfection in African American Women
Summary/Abstract: Chlamydia trachomatis (Ct) infection is the most prevalent sexually transmitted bacterial infection in the world. In the US alone, an estimated 3 million chlamydi...
A Machine Learning-Based Clinical Decision Support Tool to Predict Abdominal Aortic Aneurysm Prognosis Using Existing Longitudinal Data
SUMMARY: A Machine Learning-Based Clinical Decision Support Tool to Predict AAA Prognosis Abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta.If left untreated A...
Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged Tick
PROJECT SUMMARY Microbial residents of arthropod disease vectors engender profound effects on the biology of their host, both positive (e.g., nutrient acquisition, defense from pat...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body.These mutations originate from mutational processes due to environmental exposures, lifestyle cho...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 genetic l...
The Impact of Maternal CMV Infection on Birth Outcomes
Congenital Cytomegalovirus (CMV) infection is a leading cause of birth defects and developmental disabilities in the U.S., affecting thousands of children each year.Notably, the ma...
A data-driven approach to identify the neural and cognitive basis of social functioning in health and first episode psychosis
Project Summary/Abstract: The research and training plan for this Fellowship will provide the applicant with significant and foundational training in cognitive neuroscience, advanc...
Oral autoantigen therapy for the treatment of Multiple Sclerosis
Abstract Multiple Sclerosis affects millions of people worldwide and while the past decade has seen a wave of disease-modifying drugs and immunomodulating therapies approved by the...
Engineered ImmuneChip Platform to Study B cell Migration and Affinity Maturation
PROJECT SUMMARY Developing vaccines against emerging infections such as SARS-COV-2 and influenza requires an enhanced understanding of the underlying antibody immune response in th...
Development of zafirlukast derivatives against Porphyromonas gingivalis
Research project: Gum disease, also known as periodontal disease, is an infection that can lead to damage and inflammation of the gum and bone that surround the teeth. The early st...
Pseudomonas aeruginosa heme sensing inhibitors targeting HasAp
PROJECT SUMMARY Multidrug-resistant (MDR) Pseudomonas aeruginosa (Pa) is responsible for ~10% of nosocomial infections, highlighting the critical need for the development of novel...
Role of caspase-8 in innate immunity to infection
PROJECT SUMMARY Although inflammatory responses play a key role in controlling infection, dysregulated inflammation is associated with inflammatory and immune-mediated diseases.IL-...
The regenerative potential of the enteroblast in response to aging in Drosophila intestine
In aging animals, the intestine suffers structural and functional impairments and undergoes epithelial dysplasia.During normal tissue homeostasis, the intestinal stem cells (ISCs)...