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201,169 grants found
Showing 197,301 – 197,320 of 201,169 grants
TOPIC 382 - INTEGRATED IMAGING AND MOLECULAR ANALYSIS OF GLIOBLASTOMA USING SCOPE SEQ ON THE AIR FLOW
Clinical research is incorporating single cell analysis methods into various evaluations.During 75N91019C00029 (Phase I) of this proposed program, we intended to validate the perfo...
FINANCIAL MANAGEMENT SERVICES IN SUPPORT OF DCR SPECIAL PROJECTS (GUINEA SERVICE CENTER) FOR CONTRACT #HHSN2201700050I.
This funding supports core clinical research infrastructure to facilitate multicenter, randomized, controlled clinical trials on Ebola virus, HIV, Malaria, and other infectious dis...
The Impact of Maternal CMV Infection on Birth Outcomes
Congenital Cytomegalovirus (CMV) infection is a leading cause of birth defects and developmental disabilities in the U.S., affecting thousands of children each year.Notably, the ma...
A Machine Learning-Based Clinical Decision Support Tool to Predict Abdominal Aortic Aneurysm Prognosis Using Existing Longitudinal Data
SUMMARY: A Machine Learning-Based Clinical Decision Support Tool to Predict AAA Prognosis Abdominal aortic aneurysm (AAA) is a localized dilatation of the aorta. If left untreated...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle ch...
Epigenetic Determinants and Mechanisms Influencing Genital Chlamydia trachomatis Reinfection in African American Women
Summary/Abstract: Chlamydia trachomatis (Ct) infection is the most prevalent sexually transmitted bacterial infection in the world. In the US alone, an estimated 3 million chlamydi...
Oral autoantigen therapy for the treatment of Multiple Sclerosis
Abstract Multiple Sclerosis affects millions of people worldwide and while the past decade has seen a wave of disease-modifying drugs and immunomodulating therapies approved by the...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 genetic l...
Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged Tick
PROJECT SUMMARY Microbial residents of arthropod disease vectors engender profound effects on the biology of their host, both positive (e.g., nutrient acquisition, defense from pat...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 genetic l...
Role of caspase-8 in innate immunity to infection
PROJECT SUMMARY Although inflammatory responses play a key role in controlling infection, dysregulated inflammation is associated with inflammatory and immune-mediated diseases. IL...
Pseudomonas aeruginosa heme sensing inhibitors targeting HasAp
PROJECT SUMMARY Multidrug-resistant (MDR) Pseudomonas aeruginosa (Pa) is responsible for ~10% of nosocomial infections, highlighting the critical need for the development of novel...
Engineered ImmuneChip Platform to Study B cell Migration and Affinity Maturation
PROJECT SUMMARY Developing vaccines against emerging infections such as SARS-COV-2 and influenza requires an enhanced understanding of the underlying antibody immune response in th...
Development of zafirlukast derivatives against Porphyromonas gingivalis
Research project: Gum disease, also known as periodontal disease, is an infection that can lead to damage and inflammation of the gum and bone that surround the teeth. The early st...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle ch...
Identification of Genes and DNA Methylation Markers for Lung Cancer Risk by Integrating Multi-omics Data
Project Summary Lung cancer is the leading cause of cancer death in the United States and many other countries. Genome-wide association studies (GWAS) have identified ~55 genetic l...
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer Prevention
PROJECT SUMMARY Somatic mutations accumulate daily in every cell of the human body. These mutations originate from mutational processes due to environmental exposures, lifestyle ch...
Identifying effective and efficient approaches to tuberculosis screening in Brazilianprisons
Abstract. The goal of this career development plan is to support Dr.Leonardo Martinez, an infectious disease epidemiologist, in developing an independent research program focused o...
Dieldrin-induced differential gene methylation and parkinsonian toxicity
Project Summary The majority of Parkinson?s disease (PD) cases are not caused by an inherited monogenic mutation and disease etiology involves a combination of genetic and environm...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to...