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201,169 grants found
Showing 197,321 – 197,340 of 201,169 grants
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis.Two generations of pertussis vaccines have been developed and licensed...
Molecular basis for the regulation of IgE class switch recombination by IL-21 and STAT3
Project Summary/Abstract The incidence of allergic diseases has been steadily increasing in modernized societies and represents a major public health problem. One of the main trigg...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful v...
Contextual Predictors of Hospitalization and Quality of Life among Patients on Hemodialysis
Project Summary Over 700,000 people in the United States have end-stage kidney disease (ESKD). This number has increased by approximately 20,000 each year for over 2 decades. Some...
Dieldrin-induced differential gene methylation and parkinsonian toxicity
Project Summary The majority of Parkinson’s disease (PD) cases are not caused by an inherited monogenic mutation and disease etiology involves a combination of genetic and environm...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and license...
Identifying effective and efficient approaches to tuberculosis screening in Brazilianprisons
Abstract. The goal of this career development plan is to support Dr. Leonardo Martinez, an infectious disease epidemiologist, in developing an independent research program focused...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful v...
Molecular basis for the regulation of IgE class switch recombination by IL-21 and STAT3
Project Summary/Abstract The incidence of allergic diseases has been steadily increasing in modernized societies and represents a major public health problem. One of the main trigg...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and license...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful v...
Identifying effective and efficient approaches to tuberculosis screening in Brazilianprisons
Abstract. The goal of this career development plan is to support Dr. Leonardo Martinez, an infectious disease epidemiologist, in developing an independent research program focused...
Development of mRNA-platform vaccines
PROJECT SUMMARY Pertussis is a respiratory disease caused by the obligate human pathogen Bordetella pertussis. Two generations of pertussis vaccines have been developed and license...
Identifying effective and efficient approaches to tuberculosis screening in Brazilianprisons
Abstract. The goal of this career development plan is to support Dr. Leonardo Martinez, an infectious disease epidemiologist, in developing an independent research program focused...
Strawberry notch homologues in T cell homeostasis and function
Abstract Effective and long lasting antibody responses, which require delicate collaboration from both T and B cells, is essential for immune responses to antigens and successful v...
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopy
Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is chara...
Choroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal Fluid
Cilia are microtubule-based cellular protrusions with diverse biological functions, including fluid movement, cellular locomotion, environmental sensing, and signal transduction. T...