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DEVELOPMENT AND MAINTENANCE OF A MULTIGENOTYPIC AGED RAT COLONY PERIOD OF PERFORMANCE JANUARY 20, 2021 - JANUARY 19, 2022
Aging
Robust immune tolerance conferred by Foxp3 transcriptional regulation
Robust immune tolerance conferred by Foxp3 transcriptional regulation Regulatory T (Treg) cells actively suppress self-destructive T cells that cause a variety of autoimmune diseas...
Synaptic Mechanisms of Nucleus Accumbens Disinhibition by Ethanol
Project Summary Alcohol misuse levies a major impact on public health, yet the brain mechanisms underlying how this substance drives its misuse are poorly understood. This proposal...
PTEN promoter hypermethylation underlies vascular disease progression
ABSTRACT Atherosclerosis and restenosis are chronic and acute inflammatory vascular diseases, respectively, characterized by significant vascular remodeling. Phenotypic switching o...
Role of African-centric TP53 variant in higher H. pylori prevalence in African Americans
Project Summary African Americans have a 6-fold higher H. pylori (Hp) infection than the non-Hispanic white population; however, underlying gene(s) for this disparity remain elusiv...
Calcium Dysregulation and Cell Function in Spinal Muscular Atrophy
PROJECT SUMMARY/ABSTRACT Spinal muscular atrophy (SMA) is one of the most common inherited cause of death in infants and young children. SMA is caused by the deletion or mutation i...
Targeting the PMP22 Protein to Develop Leads Against Charcot-Marie-Tooth Disease
Project Summary Charcot-Marie-Tooth Disease (CMTD) is a debilitating hereditary peripheral neuropathy that afflicts 1:2500 humans. The hallmark of CTMD pathology is severely defect...
Elucidating the Spatiotemporal Regulation of a Long Non-Coding RNA Required for Neurodevelopment
PROJECT SUMMARY/ABSTRACT This proposal outlines a comprehensive five-year mentored career development plan with the goal of preparing the candidate, Sandeep Wontakal, M.D., Ph.D.,...
Exploring the validity of articulatory impairment phenotypes in speech motor disorders
PROJECT SUMMARY Speech motor disorders have profound impacts on an individual’s ability to communicate, often leading to a significant reduction in quality of life35,49. Since the...
A Novel Mechanism Affecting Sex Differences in Adiposity
PROJECT SUMMARY Males and females differ in adipose tissue development and function, which leads to differences in susceptibility to metabolic disorders such as type 2 diabetes. In...
Implications of Obstructive Sleep Apnea for Fat Metabolism
ABSTRACT Untreated obstructive sleep apnea (OSA) is a precursor for several cardio-metabolic complications including hypertension, insulin resistance, glucose intolerance, and type...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is chara...
Choroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal Fluid
Cilia are microtubule-based cellular protrusions with diverse biological functions, including fluid movement, cellular locomotion, environmental sensing, and signal transduction. T...
Cooperative roles of FHA and ACT in Bordetella virulence
Summary/Abstract Pertussis (aka whooping cough) is re-emerging in developed countries despite high vaccine coverage. Resurgence is due primarily to waning immunity to the causal ba...
Role of African-centric TP53 variant in higher H. pylori prevalence in African Americans
Project Summary African Americans have a 6-fold higher H. pylori (Hp) infection than the non-Hispanic white population; however, underlying gene(s) for this disparity remain elusiv...
Robust immune tolerance conferred by Foxp3 transcriptional regulation
Robust immune tolerance conferred by Foxp3 transcriptional regulation Regulatory T (Treg) cells actively suppress self-destructive T cells that cause a variety of autoimmune diseas...
Calcium Dysregulation and Cell Function in Spinal Muscular Atrophy
PROJECT SUMMARY/ABSTRACT Spinal muscular atrophy (SMA) is one of the most common inherited cause of death in infants and young children. SMA is caused by the deletion or mutation i...
PTEN promoter hypermethylation underlies vascular disease progression
ABSTRACT Atherosclerosis and restenosis are chronic and acute inflammatory vascular diseases, respectively, characterized by significant vascular remodeling. Phenotypic switching o...
Synaptic Mechanisms of Nucleus Accumbens Disinhibition by Ethanol
Project Summary Alcohol misuse levies a major impact on public health, yet the brain mechanisms underlying how this substance drives its misuse are poorly understood. This proposal...
Cooperative roles of FHA and ACT in Bordetella virulence
Summary/Abstract Pertussis (aka whooping cough) is re-emerging in developed countries despite high vaccine coverage. Resurgence is due primarily to waning immunity to the causal ba...