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201,169 grants found
Showing 197,381 – 197,400 of 201,169 grants
Robust immune tolerance conferred by Foxp3 transcriptional regulation
Robust immune tolerance conferred by Foxp3 transcriptional regulation Regulatory T (Treg) cells actively suppress self-destructive T cells that cause a variety of autoimmune diseas...
Choroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal Fluid
Cilia are microtubule-based cellular protrusions with diverse biological functions, including fluid movement, cellular locomotion, environmental sensing, and signal transduction. T...
Synaptic Mechanisms of Nucleus Accumbens Disinhibition by Ethanol
Project Summary Alcohol misuse levies a major impact on public health, yet the brain mechanisms underlying how this substance drives its misuse are poorly understood. This proposal...
PTEN promoter hypermethylation underlies vascular disease progression
ABSTRACT Atherosclerosis and restenosis are chronic and acute inflammatory vascular diseases, respectively, characterized by significant vascular remodeling. Phenotypic switching o...
Calcium Dysregulation and Cell Function in Spinal Muscular Atrophy
PROJECT SUMMARY/ABSTRACT Spinal muscular atrophy (SMA) is one of the most common inherited cause of death in infants and young children. SMA is caused by the deletion or mutation i...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is chara...
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
Abstract The goal of cancer immunotherapy is to utilize the patient’s immune system to reject the invading “foreign” tumor. However, the pancreatic cancer microenvironment is chara...
Structural and functional substrates of associative memory load in aging
PROJECT SUMMARY Healthy older adults and individuals with Alzheimer?s disease and related dementias show the most severe memory deficits for associative memory (AM), in which multi...
Pulsed Focused Ultrasound (pFUS) exposures and devices for tissue permeabilization without contrast agents
PROJECT SUMMARY According to recent reports from across the world, the need to continuously evaluate lung edema in critically ill COVID-19 patients is essential.Chest x-ray has red...
Molecular basis of heme scavenging by Gram-positive bacteria
Project Summary Nearly all species of bacteria require iron to grow because it is an essential metal cofactor that is used by microbial enzymes to mediate cellular metabolism.Durin...
Endogenous retrovirus analyses in myalgic encephalomyelitis
Project Summary/Abstract Myalgic encephalomyelitis (ME) is a disabling and complex disease with 1-2.5 million patients in the United States. ME patients have low quality of life an...
RADX-TECH- SUPPORT SERVICES NEEDED FOR WORK PACKAGE 1
We propose to develop a rapid (under 20-minute), point-of-care (PoC) Reverse Transcriptase Loop-mediated Amplification (RT-LAMP) test for the detection of SARS COV-2 virus from hum...
Structural and functional substrates of associative memory load in aging
PROJECT SUMMARY Healthy older adults and individuals with Alzheimer’s disease and related dementias show the most severe memory deficits for associative memory (AM), in which multi...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an “endocrine organ” and significantly contribute to metab...
TNRSF13B polymorphisms and the control of innate B cell responses – a double edged sword
Abstract Enteric bacterial pathogens profoundly impact the health and development of children, especially in developing countries. We unexpectedly discovered that polymorphisms of...
A novel form of light chain gene replacement
PROJECT SUMMARY B and T lymphocytes form the foundation of our adaptive immune system, which is based on specific recognition of foreign molecules by structurally diverse surface a...
Endogenous retrovirus analyses in myalgic encephalomyelitis
Project Summary/Abstract Myalgic encephalomyelitis (ME) is a disabling and complex disease with 1-2.5 million patients in the United States. ME patients have low quality of life an...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non‐coding (nc) transcriptome remains an under‐explored landscape for functional genomics. Recently, ~2,000 long non‐coding (lnc)RNAs were identified b...
Class II artificial antigen presenting cells for cancer immunotherapy
Project Summary Adoptive cell therapy (ACT) has become an increasingly attractive method for treating patients with solid tumors due to its impressive response rate; that said, the...