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201,169 grants found
Showing 197,401 – 197,420 of 201,169 grants
Pulsed Focused Ultrasound (pFUS) exposures and devices for tissue permeabilization without contrast agents
PROJECT SUMMARYAccording to recent reports from across the world, the need to continuously evaluate lung edema in critically illCOVID-19 patients is essential.Chest x-ray has reduc...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an ?endocrine organ? and significantly contribute to metab...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Role and Mechanism of Blood Pressure Variability in Risk of Heart Failure
Project Summary/Abstract Blood pressure variability (BPv) is increasingly appreciated as a risk factor for cardiovascular disease.However, few studies have examined the relationshi...
Class II artificial antigen presenting cells for cancer immunotherapy
Project Summary Adoptive cell therapy (ACT) has become an increasingly attractive method for treating patients with solid tumors due to its impressive response rate; that said, the...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non?coding (nc) transcriptome remains an under?explored landscape for functional genomics.Recently, ~2,000 long non?coding (lnc)RNAs were identified by...
A novel form of light chain gene replacement
PROJECT SUMMARY B and T lymphocytes form the foundation of our adaptive immune system, which is based on specific recognition of foreign molecules by structurally diverse surface a...
TNRSF13B polymorphisms and the control of innate B cell responses – a double edged sword
Abstract Enteric bacterial pathogens profoundly impact the health and development of children, especially in developing countries.We unexpectedly discovered that polymorphisms of t...
Role and Mechanism of Blood Pressure Variability in Risk of Heart Failure
Project Summary/Abstract Blood pressure variability (BPv) is increasingly appreciated as a risk factor for cardiovascular disease. However, few studies have examined the relationsh...
Molecular basis of heme scavenging by Gram-positive bacteria
Project Summary Nearly all species of bacteria require iron to grow because it is an essential metal cofactor that is used by microbial enzymes to mediate cellular metabolism. Duri...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non‐coding (nc) transcriptome remains an under‐explored landscape for functional genomics. Recently, ~2,000 long non‐coding (lnc)RNAs were identified b...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an “endocrine organ” and significantly contribute to metab...
Role and Mechanism of Blood Pressure Variability in Risk of Heart Failure
Project Summary/Abstract Blood pressure variability (BPv) is increasingly appreciated as a risk factor for cardiovascular disease. However, few studies have examined the relationsh...
Mechanisms of microcystin-induced hepatocellular carcinoma in nonalcoholic steatohepatitis
Microcystin-LR (MCLR) is the most potent and abundant cyanotoxin produced by freshwater blue-green algae. MCLR exposure is associated with nonalcoholic fatty liver disease (NAFLD)...
Biogenesis and function of a novel class of stress-induced long non-coding RNAs
ABSTRACT/PROJECT SUMMARY The non‐coding (nc) transcriptome remains an under‐explored landscape for functional genomics. Recently, ~2,000 long non‐coding (lnc)RNAs were identified b...
Molecular basis of heme scavenging by Gram-positive bacteria
Project Summary Nearly all species of bacteria require iron to grow because it is an essential metal cofactor that is used by microbial enzymes to mediate cellular metabolism. Duri...
Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations
Project Summary/Abstract Human gut microbiota, with its massive catalytical capacity and functional potential, may act as an “endocrine organ” and significantly contribute to metab...
PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns
SUMMARY To improve patient outcomes, BioAesthetics is developing an acellular human dermal substitute for single-stage reconstruction of full-thickness burns.Nearly half a million...
AADR Bloc Travel Grant for Dental Students and NIDCR Supported Trainees
Project Summary The American Association for Dental Research (AADR) Bloc Travel Grant for Dental Students and NIDCR-Supported Trainees aims to target a diverse pipeline of the dent...