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201,169 grants found
Showing 197,421 – 197,440 of 201,169 grants
Lipid Metabolism-driven Drug Resistance in Multiple Myeloma
Abstract Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells primarily in the bone marrow and has a 5-year survival rate of only 50%. Obesity increase...
X-ray Visualized Interbody Spacer Indicating Biomechanical Load (X-VISIBL) Fusion Device
Abstract Spine disorders, primarily caused by degenerative spine conditions, deformity, tumors, and trauma, affect approximately half of the population aged over 40.To address thes...
Driving Skills of Adolescents with Obstructive Sleep Apnea (OSA)
Project Summary Despite major public health efforts, auto crashes remain by far the leading cause of death among 16-19-year-olds and are a major cause of non-fatal injuries.There i...
Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools: Equipment Supplement
PROJECT SUMMARY / ABSTRACT The Nonhuman Primate Testing Center for Evaluation of Somatic Cell Genome Editing Tools supports studies in nonhuman primates that advance the genome edi...
PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns
PROJECT SUMMARY BioAesthetics is developing a novel acellular graft for improved burn wound healing.Our patent- pending drug-loaded, polymer-integrated acellular biologic graft (PC...
Intermittent hypoxia and hypertension: Role of the lamina terminalis
The central objective of this research program is to determine the role of the CNS in hypertension associated with chronic intermittent hypoxia (CIH), a model of hypoxemia associat...
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Assisted Identification and Navigation of Early Mental Health Symptoms in Children
ABSTRACT About 55% of children with significant mental health difficulties receive treatment and up to 80% of children with sub-clinical symptoms receive no treatment. Treatments a...
High-resolution mapping of the human brainstem during continence and micturition: noninvasive in vivo 7 Tesla fMRI study
The lower urinary tract (LUT) – bladder, bladder neck, urethra, and urethral sphincter – is controlled by a complex neural network. A delicate and complex switch/relay exists betwe...
Interplay of Sex Hormones and Chromosomes in Vascular Oxidative Stress and Arterial Stiffening
Project Summary Sex steroids and chromosomes both contribute to the sexual dimorphism in CVD. Vascular oxidative stress is one mechanism that is elevated in men compared with women...
Defining Chlamydia trachomatis adhesion factor epitope-specific antibody responses, functionality, and roles in protection against urogenital infection
PROJECT SUMMARY Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection worldwide and causes serious medical complications in women, including pelvic...
AADR Bloc Travel Grant for Dental Students and NIDCR Supported Trainees
Project Summary The American Association for Dental Research (AADR) Bloc Travel Grant for Dental Students and NIDCR-Supported Trainees aims to target a diverse pipeline of the dent...
Assisted Identification and Navigation of Early Mental Health Symptoms in Children
ABSTRACT About 55% of children with significant mental health difficulties receive treatment and up to 80% of children with sub-clinical symptoms receive no treatment. Treatments a...
Care Team and Practice Level Implementation Strategies to Optimize Pediatric Collaborative Care: A Cluster-Randomized Trial
PROJECT SUMMARY/ABSTRACT Chronic care models (CCM) that deliver evidence-based practices (EBP) by multidisciplinary provider teams with primary care physicians (PCP) and behavioral...
Defining Chlamydia trachomatis adhesion factor epitope-specific antibody responses, functionality, and roles in protection against urogenital infection
PROJECT SUMMARY Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection worldwide and causes serious medical complications in women, including pelvic...
Intermittent hypoxia and hypertension: Role of the lamina terminalis
The central objective of this research program is to determine the role of the CNS in hypertension associated with chronic intermittent hypoxia (CIH), a model of hypoxemia associat...
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Lipid Metabolism-driven Drug Resistance in Multiple Myeloma
Abstract Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells primarily in the bone marrow and has a 5-year survival rate of only 50%. Obesity increase...
PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns
SUMMARY To improve patient outcomes, BioAesthetics is developing a drug-eluting acellular dermal graft for single-stage reconstruction of full-thickness burns. Nearly half a millio...
Assisted Identification and Navigation of Early Mental Health Symptoms in Children
ABSTRACT About 55% of children with significant mental health difficulties receive treatment and up to 80% of children with sub-clinical symptoms receive no treatment. Treatments a...