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201,169 grants found
Showing 197,441 – 197,460 of 201,169 grants
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Assisted Identification and Navigation of Early Mental Health Symptoms in Children
ABSTRACT About 55% of children with significant mental health difficulties receive treatment and up to 80% of children with sub-clinical symptoms receive no treatment. Treatments a...
Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma
PROJECT SUMMARY Extracellular vesicles (EVs) are a heterogeneous group of phospholipid bilayer-enclosed particles that are released by all types of cells, and even more so by tumor...
Intermittent hypoxia and hypertension: Role of the lamina terminalis
The central objective of this research program is to determine the role of the CNS in hypertension associated with chronic intermittent hypoxia (CIH), a model of hypoxemia associat...
High-resolution mapping of the human brainstem during continence and micturition: noninvasive in vivo 7 Tesla fMRI study
The lower urinary tract (LUT) ? bladder, bladder neck, urethra, and urethral sphincter ? is controlled by a complex neural network.A delicate and complex switch/relay exists betwee...
Interplay of Sex Hormones and Chromosomes in Vascular Oxidative Stress and Arterial Stiffening
Project Summary Sex steroids and chromosomes both contribute to the sexual dimorphism in CVD.Vascular oxidative stress is one mechanism that is elevated in men compared with women...
Defining Chlamydia trachomatis adhesion factor epitope-specific antibody responses, functionality, and roles in protection against urogenital infection
PROJECT SUMMARY Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection worldwide and causes serious medical complications in women, including pelvic...
AADR Bloc Travel Grant for Dental Students and NIDCR Supported Trainees
Project Summary The American Association for Dental Research (AADR) Bloc Travel Grant for Dental Students and NIDCR-Supported Trainees aims to target a diverse pipeline of the dent...
Care Team and Practice Level Implementation Strategies to Optimize Pediatric Collaborative Care: A Cluster-Randomized Trial
PROJECT SUMMARY/ABSTRACT Chronic care models (CCM) that deliver evidence-based practices (EBP) by multidisciplinary provider teams with primary care physicians (PCP) and behavioral...
Lipid Metabolism-driven Drug Resistance in Multiple Myeloma
Abstract Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells primarily in the bone marrow and has a 5-year survival rate of only 50%. Obesity increase...
Care Team and Practice Level Implementation Strategies to Optimize Pediatric Collaborative Care: A Cluster-Randomized Trial
PROJECT SUMMARY/ABSTRACT Chronic care models (CCM) that deliver evidence-based practices (EBP) by multidisciplinary provider teams with primary care physicians (PCP) and behavioral...
Intermittent hypoxia and hypertension: Role of the lamina terminalis
The central objective of this research program is to determine the role of the CNS in hypertension associated with chronic intermittent hypoxia (CIH), a model of hypoxemia associat...
PHMB-Impregnated Acellular Biologic Grafts for Treatment of Third-Degree Burns
SUMMARY To improve patient outcomes, BioAesthetics is developing a drug-eluting acellular dermal graft for single-stage reconstruction of full-thickness burns. Nearly half a millio...
Care Team and Practice Level Implementation Strategies to Optimize Pediatric Collaborative Care: A Cluster-Randomized Trial
PROJECT SUMMARY/ABSTRACT Chronic care models (CCM) that deliver evidence-based practices (EBP) by multidisciplinary provider teams with primary care physicians (PCP) and behavioral...
Molecular determinants of fetal hemoglobin induction by hydroxyurea to treat sickle cell disease
Project Summary Highly proliferative cells need to coordinate their gene expression programs with cellular metabolism and nutrient availability.However, we have a poor understandin...
Characterizing Shared Features of Innate Immune Cells across Neurodegenerative Diseases using Single Cell Expression and Chromatin Accessibility Data
With few effective interventions available and over 10 million patients affected, neurodegenerative diseases are an area of intense basic science and clinical research.Inspired by...
Childhood Anxiety: The Contributions of Effortful Control, Interpretation Biases, and Early Life Stress
PROJECT SUMMARY/ABSTRACT This is an application for a National Research Service Award (NRSA) Individual Predoctoral Fellowship to support the academic career development of the app...
The role of chromatin dynamics in stochastic cell fate specification
Project Summary: Stochastic cell fate specification, in which cells randomly choose between cell fates, is critical during development. Stochastic mechanisms diversify visual and o...
TGF-b superfamily signaling in controlling Th17 cell function in autoimmune neuroinflammation
Project Summary: Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammation disease inflicting millions of people worldwide. It is caused by dysregulated adaptive and i...
TGF-b superfamily signaling in controlling Th17 cell function in autoimmune neuroinflammation
Project Summary: Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammation disease inflicting millions of people worldwide. It is caused by dysregulated adaptive and i...