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201,169 grants found
Showing 197,461 – 197,480 of 201,169 grants
Causal testing of the role of a place code for global-scale visual features in primate V1 using patterned optogenetics
Humans are highly sensitive to the overall shape of objects—a critical step in object identification. One hypothesis is that the brain uses the shape of the spread of stimulus-evok...
The role of chromatin dynamics in stochastic cell fate specification
Project Summary: Stochastic cell fate specification, in which cells randomly choose between cell fates, is critical during development. Stochastic mechanisms diversify visual and o...
Molecular determinants of fetal hemoglobin induction by hydroxyurea to treat sickle cell disease
Project Summary Highly proliferative cells need to coordinate their gene expression programs with cellular metabolism and nutrient availability. However, we have a poor understandi...
Molecular determinants of fetal hemoglobin induction by hydroxyurea to treat sickle cell disease
Project Summary Highly proliferative cells need to coordinate their gene expression programs with cellular metabolism and nutrient availability. However, we have a poor understandi...
TGF-b superfamily signaling in controlling Th17 cell function in autoimmune neuroinflammation
Project Summary: Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammation disease inflicting millions of people worldwide. It is caused by dysregulated adaptive and i...
Childhood Anxiety: The Contributions of Effortful Control, Interpretation Biases, and Early Life Stress
PROJECT SUMMARY/ABSTRACT This is an application for a National Research Service Award (NRSA) Individual Predoctoral Fellowship to support the academic career development of the app...
The role of chromatin dynamics in stochastic cell fate specification
Project Summary: Stochastic cell fate specification, in which cells randomly choose between cell fates, is critical during development. Stochastic mechanisms diversify visual and o...
Causal testing of the role of a place code for global-scale visual features in primate V1 using patterned optogenetics
Humans are highly sensitive to the overall shape of objects?a critical step in object identification.One hypothesis is that the brain uses the shape of the spread of stimulus-evoke...
TGF-b superfamily signaling in controlling Th17 cell function in autoimmune neuroinflammation
Project Summary: Multiple sclerosis (MS) is a debilitating autoimmune neuroinflammation disease inflicting millions of people worldwide. It is caused by dysregulated adaptive and i...
Evaluating a Combined Communication and Counseling Intervention in Primary Progressive Aphasia: A Pilot Feasibility Study
Project Summary Aphasia is a neurogenic communication disorder caused by damage to language regions in the brain, including acute neurological insult or neurodegenerative disease.1...
Causal testing of the role of a place code for global-scale visual features in primate V1 using patterned optogenetics
Humans are highly sensitive to the overall shape of objects—a critical step in object identification. One hypothesis is that the brain uses the shape of the spread of stimulus-evok...
Characterizing Shared Features of Innate Immune Cells across Neurodegenerative Diseases using Single Cell Expression and Chromatin Accessibility Data
With few effective interventions available and over 10 million patients affected, neurodegenerative diseases are an area of intense basic science and clinical research. Inspired by...
Molecular determinants of fetal hemoglobin induction by hydroxyurea to treat sickle cell disease
Project Summary Highly proliferative cells need to coordinate their gene expression programs with cellular metabolism and nutrient availability. However, we have a poor understandi...
The impact of post acute care payment changes on access and outcomes
Project Summary/Abstract Substantial changes in Medicare payment policies are occurring for post-acute care (PAC), which provides a bridge from the hospital to home for individuals...
Adaptive optical microscopy for high-accuracy recording of neural activity in vivo
PROJECT SUMMARY To understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy, which requires methodologies with high spatial and...
UAB Research in Aging through Mentorship and Practice - Undergraduate Program (UAB RAMP-UP)
Despite efforts to increase the number of underrepresented researchers in universities across the country, there is a continued lack of diversity in Aging Research. The goal of the...
Skeleton and Joint Degeneration with Aging
PROJECT SUMMARY/ABSTRACT Decreased mobility significantly increases the risk of many chronic diseases leading to an acceleration of the normal aging process.Skeletal degeneration,...
Admin Core
Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75-years), primarily through the elimination of lives lost due to premature...
In Vivo Model and Histology Core
PROJECT SUMMARY The purpose of the in vivo Animal model & histology core is to consolidate key personnel and equipment to provide a centralized facility that will enhance colla...
Endplate Sensory Innervations for LBP
ABSTRACT Persistent pain, particularly at rest, profoundly affects quality of life and daily physical activity, especially in the elderly population. Pain itself is a risk factor f...