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201,169 grants found
Showing 197,521 – 197,540 of 201,169 grants
Adaptive optical microscopy for high-accuracy recording of neural activity in vivo
PROJECT SUMMARY To understand the computations in the brain, we need to monitor the activity of neural circuits at high accuracy, which requires methodologies with high spatial and...
Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention
The prevalence of Alzheimer's Disease and other disorders (ADRDs) is now a public health crisis. In the absence of effective medical treatment, there is a critical need for be...
An ounce of prevention: stopping menopausal bone loss before it starts
Summary The aphorism “an ounce of prevention is worth a pound of cure” very much applies to postmenopausal osteoporosis. Immediately following menopause, bone loss rates can reach...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers
This is a K01 award application for Dr. Jacqueline Eaton, a gerontologist and young investigator pursuing transdisciplinary research on enhancing the quality of life of older adult...
Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis
PROJECT SUMMARY/ABSTRACT The overarching goal of my proposal is to acquire technical and professional skills to become an independent investigator at a leading academic institution...
Single cell, whole genome analysis of the aging human cardiomyocyte
Project Summary/Abstract Recent evidence suggests that environmental factors causing somatic mutations during the lifetime have a more crucial role, not only in cancer but also in...
Investigating the Roles of Phospholipase A2s and Diacylglycerol Signaling in Ferroptosis
PROJECT SUMMARY Despite rapid advances in cancer therapeutic development, acquired drug resistance continues to threaten the long-term efficacy of existing chemotherapeutic agents,...
Skeleton and Joint Degeneration with Aging
PROJECT SUMMARY/ABSTRACT Decreased mobility significantly increases the risk of many chronic diseases leading to an acceleration of the normal aging process. Skeletal degeneration,...
Admin Core
Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75-years), primarily through the elimination of lives lost due to premature...
In Vivo Model and Histology Core
PROJECT SUMMARY The purpose of the in vivo Animal model & histology core is to consolidate key personnel and equipment to provide a centralized facility that will enhance colla...
Endplate Sensory Innervations for LBP
ABSTRACTPersistent pain, particularly at rest, profoundly affects quality of life and daily physical activity, especially in the elderly population. Pain itself is a risk factor fo...
PTH Attenuation of Spinal Degeneration During Aging PI Janet Crane
SUMMARY Low back pain is the leading cause of disability, driven predominantly by aging. Pain contributes to frailty by lowering quality of life and limiting physical activities. I...
Senescence of Pre-Osteoclasts in Non-Traumatic OA
SUMMARY/ABSTRACT Osteoarthritis (OA) is the most prevalent age-associated chronic joint disease. Although direct joint injury and excessive mechanical overloading are considered as...
Stem Cell Surface Modification to Promote Nerve Regeneration
Project Summary Peripheral nerve injury, especially critical-sized nerve gap injury, often results in poor recovery of function andimpaired quality of life for the patient. Stem ce...
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients. An example is a type of blood cancer, kn...
UAB Research in Aging through Mentorship and Practice - Undergraduate Program (UAB RAMP-UP)
Despite efforts to increase the number of underrepresented researchers in universities across the country, there is a continued lack of diversity in Aging Research. The goal of the...
Improving risk prediction of adverse outcomes in hemodialysis patients by incorporating non-traditional risk factors
PROJECT SUMMARY: Candidate: The primary objective of this application is to support Dr. Lili Chan's career development into an independently funded clinical investigator lever...
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults at Risk of Alzheimer's Disease and Related Dementias
PROJECT SUMMARY The overall objective of the proposed work is to understand factors mediating and moderating transfer of learning in the context of training Working Memory (WM) sys...
Black Male Brain Reserve, Resilience & Alzheimer’s Disease: Life Course Perspectives
Project Summary/Abstract: The United States has invested significant resources through innovative research to address the profound effects of Alzheimer?s Disease, and Alzheimer?s D...