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201,169 grants found
Showing 197,561 – 197,580 of 201,169 grants
Training Promotoras/Community Health Workers using Culturally and Linguistically-Appropriate Research Best Practices
Project Summary Good clinical practice is essential training for the clinical research workforce that supports the integrity and rigor of clinical research during implementation.Wh...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Hypothalamic and metabolic dysfunction in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the most common cause of dementia in the elderly with currently no cure or effective disease-modifying therapy. The pathogenesi...
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
ABSTRACT. Colorectal cancer (CRC) is associated with multiple risk factors including, obesity, low fiber diets, and diets high in animal protein and saturated fat (SFat). African A...
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
PROJECT SUMMARY / ABSTRACT Staphylococcus epidermidis is a ubiquitous member of the human skin and mucosal microbiota. Functionally, it is a key contributor to human health via imm...
Behavioral and Neural Target Engagement for ADHD Executive Working Memory Training
Many investigators have attempted to show that using intensive cognitive training to increase Attention- Deficit/Hyperactivity Disorder (ADHD) patients’ capacity to store informati...
Global Cooperation to Promote Clinical Research in Children
FDA PA 19-306 Project Summary Bierer, Barbara E., M.D. Global Cooperation to Promote Clinical Research in Children Project Summary The Multi-Regional Clinical Trial (MRCT) Center o...
Investigation of Mechanosensory Signaling in the Pathogenesis of Traumatic Brain Injury in Human iPSC-derived Cortical Brain Organoids
Project Summary/Abstract Global incidence of Traumatic Brain Injury (TBI) is on the rise, particularly among athletes, military personnel, and elderly citizens1. TBI represents a s...
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI
ABSTRACT Traumatic brain injury (TBI) is significantly correlated with increased risk for developing several neurodegenerative disorders, including Alzheimer’s Disease (AD) and AD-...
Investigating the Effect of Antibody Mediated Feedback on B Cell Clonal Selection
Project Summary/Abstract High affinity antibody titers elicited by infection or vaccination form the basis for protection against reinfection. However, preexisting antigen-specific...
THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT
Project Summary/Abstract Although HIV-infected patients in the western world have a life expectancy near that of the general population, they are at a significantly elevated risk o...
Sptlc3-derived sphingolipids in cardiomyocyte death in ischemia
Project Summary Ischemic cardiomyopathy is the leading cause of death in the world and affects approximately 1% to 2% of the general population. Sphingolipids including ceramides a...
Mesodermal Commitment of the Definitive Hematopoietic Program
PROJECT SUMMARY / ABSTRACT The overall goal of our research is to understand the origin, development and regulation of the embryonic progenitor to the hematopoietic stem cell (HSC)...
Management of Complex Medication Regimens among Older Adults with Alzheimer's Disease and Related Dementias and their Caregivers
PROJECT SUMMARY Alzheimer’s disease and related dementias (ADRD) are progressive diseases characterized by their debilitating impact on cognitive function. Adults ages 65-years and...
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Intimate partner violence (IPV), the physical violence, sexual violence, psychological aggression, or stalking by a current or former intimate partner, is a significant public heal...
Bruins in Genomics: Dental, Oral & Craniofacial Research Training Program (BIG DOC)
The proposed R25-NIDCR Research Education in Genomics Training Program with Diversity Action Plan (DAP) is to provide summer research experience in Genomic Sciences, Medicine and S...
Black Male Brain Reserve, Resilience & Alzheimer’s Disease: Life Course Perspectives
Project Summary/Abstract: The United States has invested significant resources through innovative research to address the profound effects of Alzheimer’s Disease, and Alzheimer’s D...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plasticit...
Me & You-Tech: A socio-ecological solution to teen dating violence for the digital age.
ABSTRACT The goal of this 3-year Fast-Track STTR is to develop and evaluate a multi-level (youth, parent, school) Internet-based dating violence (DV) prevention program, ‘Me &...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug targets a...