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201,169 grants found
Showing 197,601 – 197,620 of 201,169 grants
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
PROJECT SUMMARY/ABSTRACT The apolipoprotein E epsilon 4 (APOE 4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD). A recent review by...
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning Summa...
Skeleton and Joint Degeneration with Aging
PROJECT SUMMARY/ABSTRACT Decreased mobility significantly increases the risk of many chronic diseases leading to an acceleration of the normal aging process. Skeletal degeneration,...
Admin Core
Over the past century, mean life expectancy in the United States has increased more than 50% (from 47 to 75-years), primarily through the elimination of lives lost due to premature...
In Vivo Model and Histology Core
PROJECT SUMMARY The purpose of the in vivo Animal model & histology core is to consolidate key personnel and equipment to provide a centralized facility that will enhance colla...
Endplate Sensory Innervations for LBP
ABSTRACTPersistent pain, particularly at rest, profoundly affects quality of life and daily physical activity, especially in the elderly population. Pain itself is a risk factor fo...
PTH Attenuation of Spinal Degeneration During Aging PI Janet Crane
SUMMARY Low back pain is the leading cause of disability, driven predominantly by aging. Pain contributes to frailty by lowering quality of life and limiting physical activities. I...
Senescence of Pre-Osteoclasts in Non-Traumatic OA
SUMMARY/ABSTRACT Osteoarthritis (OA) is the most prevalent age-associated chronic joint disease. Although direct joint injury and excessive mechanical overloading are considered as...
UAB Research in Aging through Mentorship and Practice - Undergraduate Program (UAB RAMP-UP)
Despite efforts to increase the number of underrepresented researchers in universities across the country, there is a continued lack of diversity in Aging Research. The goal of the...
Compensation Training and Lifestyle Modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention
The prevalence of Alzheimer's Disease and other disorders (ADRDs) is now a public health crisis. In the absence of effective medical treatment, there is a critical need for be...
ENIGMA World Aging Center
ABSTRACTOne in three seniors dies with Alzheimer’s disease (AD) or another dementia - diseases that cost the nation $259 billion, to rise to $1.1 trillion by 2050 (Alzheimer’s Asso...
Molecular mechanisms underlying cortical interneuron synaptic specificity
Project Summary/Abstract Cortical inhibitory GABAergic interneurons (INs), which develop intricate local circuits, critically regulate higher- order brain functions by balancing an...
Structure and function of mammalian CPEB2 aggregates in normal and AD brain
Project Summary The aggregate failure of pre-clinical and clinical trials in AD has demonstrated that an improved fundamental understanding of memory and how the molecular componen...
NERO Annual Conference & Training Seminar 2021 - 2025
National Egg Regulatory Officials Annual Conference & Training Seminar Project Summary The National Egg Regulatory Officials (NERO) submits this proposal to the Food And Drug A...
Humanization of a Notch 3 Agonist Antibody for Pre-Clinical Development of a CADASIL Treatment
PROJECT SUMMARY Notch 3 mutations are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a small vessel disease char...
Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults
OTHER PROJECT INFORMATION – Project Summary/Abstract Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults The rapid aging of the U.S. population, with...
The impact of post acute care payment changes on access and outcomes
Project Summary/Abstract Substantial changes in Medicare payment policies are occurring for post-acute care (PAC), which provides a bridge from the hospital to home for individuals...
Investigating the Roles of Phospholipase A2s and Diacylglycerol Signaling in Ferroptosis
PROJECT SUMMARY Despite rapid advances in cancer therapeutic development, acquired drug resistance continues to threaten the long-term efficacy of existing chemotherapeutic agents,...
Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers
PROJECT ABSTRACT The rate of Alzheimer’s Disease and related dementias (AD/ADRD) is nearly twice as high among African Americans when compared to Whites. African Americans are more...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...