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201,169 grants found
Showing 197,801 – 197,820 of 201,169 grants
Humanization of a Notch 3 agonist antibody for pre-clinical development of a CADASIL treatment
PROJECT SUMMARY Notch 3 mutations are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a small vessel disease char...
Building transgenic tools in Acomys cahirinus, an emerging model for mammalian regenerative biology and healthy aging
Project Summary Many of the major biological discoveries of the 20th century were made using very few model species.They were chosen for historical tractability, rather than biolog...
Adult-Daughter Caregivers Pursuit of Personal Physical Activity Goals: The ACHIEVE Study
PROJECT SUMMARY/ABSTRACT As the United States population grows increasingly older, millions of U.S. women find themselves providing care for older parents with Alzheimer?s disease...
Developing a clinical and research framework for evaluating inflammation pathway dysregulation in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) is the most common cause of dementia worldwide. In the US, it is the fifth leading cause of death in people over 65-years of...
Development of isogenic iPSC cell lines expressing tauopathy-related PERK risk variants to study homeostatic control of protein levels during ER stress
Project Summary In neurodegenerative diseases, accumulation of misfolded proteins is the pathological hallmark. Levels of the toxic proteins, such as tau, correspond to cellular dy...
A pilot randomized trial of video-based family therapy for home-visited mothers with perinatal depressive symptoms
PROJECT SUMMARY The Maternal, Infant, and Early Childhood Home Visiting Program is a national child abuse prevention strategy that serves vulnerable families throughout the United...
New Survey Measures of Mortality at Older Ages in Low and Middle-Income Countries
PROJECT SUMMARY Following large declines in childhood mortality and progress in lowering mortality from causes of death that affect young adults, mortality is rapidly shifting to a...
Differential Diagnosis of recurrent GBM versus Radiation Necrosis using MDSCbiomarkers
One major clinical challenge for diagnosis of recurrent glioblastoma (GBM) is assessment of response to treatment. While standard chemo-radiotherapy improves survival, it also comp...
Define molecular events driving selective neuronal death in multiple neurodegenerative diseases by snRNA-seq
Project Summary Despite decades of research, currently the mechanisms of neurodegeneration in Alzheimer?s disease (AD) and Parkinson Disease (PD) remain controversial and there are...
Transcriptomic and epigenomic landscape of neurodegenerative disease models
Project Summary This proposal seeks to characterize the transcriptome and epigenome of genetic models of Alzheimer's disease (AD) in Drosophila melanogaster.We will use a comp...
Investigation of the role of glia cells in Alzheimers pathogenesis in a functional human-based in vitro model
Scientific Abstract / Summary Alzheimer?s disease (AD) is the most prevalent neurodegenerative disorder characterized by progressive cognitive decline that leads to age-related dem...
Toward precision medicine: modulation of ABCA7 associated risk of Alzheimer's disease by ancestry
Abstract Ethnic and cultural diversity offers economic and societal benefits. It also poses challenges in therapeutic development and health care provision.However, ancestry has no...
Mechanisms of caspase-2 activation by nucleophosmin in AML cell death and survival
PROJECT SUMMARY The high rate of recurrence and treatment-related mortalities in pediatric acute myeloid leukemia (AML) under- scores the critical need to develop targeted therapie...
Developing a screening platform to identify inhibitors of pathological self-assembly of Tau
Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disorder that currently affects an estimated 5.7 million individuals in the USA. This age onset disord...
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
PROJECT SUMMARY/ABSTRACT The apolipoprotein E epsilon 4 (APOE ?4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD).A recent review by t...
Characterizing upstream regulators of glucosylceramide metabolism for Parkinson's disease and Lewy Body Dementia
Parkinson?s disease (PD)-associated dementia and Lewy Body Dementia (LBD) incidence is high among the aged population with 1% of those over 60 and 4% of those over 80. Mutations in...
A Commercially Durable Biobank of Genetically Diverse and Differentiation Competent Primary Airway Progenitor Cells Validated for In Vitro Toxicology Screening
Project Abstract While primary human airway epithelial cells (hAECs) have seen increasing use as models for in vitro toxicology screening, there remain severe drawbacks to their br...
Mesodermal Commitment of the Definitive Hematopoietic Program
PROJECT SUMMARY / ABSTRACT The overall goal of our research is to understand the origin, development and regulation of the embryonic progenitor to the hematopoietic stem cell (HSC)...
Formyl peptide receptor activation induces vascular plasticity and remodeling in hypertension
PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown tha...
Optical control of endogenous G protein Coupled Receptor and G Protein Signaling.
Abstract Cells sense the extracellular environment primarily using G protein-coupled receptors (GPCRs).They represent the largest family of cell surface proteins and play key physi...