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201,169 grants found
Showing 197,841 – 197,860 of 201,169 grants
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning Summa...
Improving risk prediction of adverse outcomes in hemodialysis patients by incorporating non-traditional risk factors
PROJECT SUMMARY: Candidate: The primary objective of this application is to support Dr.Lili Chan's career development into an independently funded clinical investigator levera...
Association of Perceived Stress and Cognition
Project/Summary Abstract African Americans are twice as likely to develop Alzheimer's disease (AD) as Whites, but few studies have focused on these cognitive disparities and r...
Elucidating the role of microglia and neurotrophin receptor p75 on neuronal degeneration in frontotemporal dementia
Frontotemporal dementia (FTD) comprises a group of early-onset neurodegenerative diseases characterized by widespread neuronal degeneration in the central nervous system leading to...
Prefrontal ensemble dynamics during response execution and inhibition
PROJECT SUMMARY/ABSTRACT The balance between response execution and response inhibition (i.e., going vs. not-going or stopping) plays a fundamental role in regulating normal behavi...
Longitudinal Measurement of Neurodegeneration in two Murine Models of Multiple Sclerosis: A Clinical and Histopathologic Validation Study
PROJECT SUMMARY Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system whereby relentless demyelination and neuroaxonal loss are the...
Point-of-Care Rapid RNA test for Zika
Point-of-Care Rapid RNA test for Zika CrossLife Technologies Inc.Project Summary/Abstract We aim to develop a rapid point-of-test that detects ZIKV at the point-of-need in < 30...
Improving the performance of an AI-enabled clinical decision support tool for detecting suicidal risk and other mental health concerns
PROJECT SUMMARY?Clarigent Health is refining an AI-enabled clinical decision support tool that uses linguistic and acoustic patterns in recorded patient interviews to identify pati...
High-throughput testing of anti-aging and FDA approved drugs in genetically diverse invertebrate Alzheimer's models
Project Abstract Alzheimer?s disease (AD) is the leading cause of dementia, with incidence on the rise?clearly central to a global health crisis.Clinical symptoms often manifest as...
Engineering biomimetic artificial antigen presenting cells for Type 1 Diabetes immunotherapy
Project Summary The overall goal of this project is to design and implement a biomimetic artificial antigen presenting cell platform to treat Type 1 Diabetes (T1D).T1D is a life-th...
Investigation of Mechanosensory Signaling in the Pathogenesis of Traumatic Brain Injury in Human iPSC-derived Cortical Brain Organoids
Project Summary/Abstract Global incidence of Traumatic Brain Injury (TBI) is on the rise, particularly among athletes, military personnel, and elderly citizens1.TBI represents a sp...
Sptlc3-derived sphingolipids in cardiomyocyte death in ischemia
Project Summary Ischemic cardiomyopathy is the leading cause of death in the world and affects approximately 1% to 2% of the general population.Sphingolipids including ceramides an...
Role of ROCK isoform-mediated actin cytoskeleton modification in the pathogenesis of heart disease
PROJECT ABSTRACT The prevention and treatment of heart disease remain challenging. Rho kinase (also named ROCK) has recently emerged as a potential therapeutic target for various c...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory cel...
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
PROJECT SUMMARY / ABSTRACT Staphylococcus epidermidis is a ubiquitous member of the human skin and mucosal microbiota. Functionally, it is a key contributor to human health via imm...
A comprehensive quality control testing strategy for engineered cells
ABSTRACT KromaTiD?s current commercial therapeutic gene editing customers have expressed the critical need for a standard approach to screening engineered cells for quality and saf...
Stem Cell Surface Modification to Promote Nerve Regeneration
Project Summary Peripheral nerve injury, especially critical-sized nerve gap injury, often results in poor recovery of function and impaired quality of life for the patient.Stem ce...
The Progeria Research Foundation 10th International Scientific Workshop, "Researching Possibilities, ExTENding Lives
Overview: Hutchinson-Gilford progeria syndrome (HGPS or Progeria) is a rare, fatal segmental premature aging disease caused by a splice site mutation in the LMNA gene.Children with...
Engineering a novel biomaterial for oxygen transport applications
Abstract Hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine.Despite significant co...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plasticit...