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201,169 grants found
Showing 197,861 – 197,880 of 201,169 grants
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
Protein S (PS) is a unique protein because it functions non-enzymatically as an anticoagulant, and because it interacts with plasma components that function in both hemostasis and...
Leveraging platelet contraction cytometry for immune thrombocytopenia
PROJECT SUMMARY/ABSTRACT Defined by low platelet count in the absence of any other cause, immune thrombocytopenic purpura (ITP) affects over 4,000 US children and 8,000 adults each...
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
ABSTRACT Menopause is an inevitable stage in normal human aging, affecting the quality of life of millions of women all over the world. Menopausal symptoms including hot flushes, s...
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
ABSTRACT To infect airway epithelial cells, influenza A virus (IAV) must penetrate the secreted mucus and underlying periciliary layer barriers – both comprised, in large part, of...
Investigating the Effect of Antibody Mediated Feedback on B Cell Clonal Selection
Project Summary/Abstract High affinity antibody titers elicited by infection or vaccination form the basis for protection against reinfection.However, preexisting antigen-specific...
Imaging Bacterial Infections in Vivo: First in Man Studies
Project Summary/Abstract Infection is the major complication of virtually all medical devices.It is estimated that 2 million patients acquire a nosocomial infection in the US every...
Epigenetic-metabolic aspects of alcohol use disorder and early developmental alcohol exposure
PROJECT SUMMARY/ABSTRACT Alcohol use disorder (AUD) continues to impose a tremendous burden on society and efficacious treatment options are severely lacking. Recently, epigenetic...
Drug Discovery Pipeline Targeting Pathologically Leaky Calcium Release Channels in Age-Related Indications
Project Summary Photonic Pharma LLC (PP) proposes a Phase I SBIR project to launch high-throughput screening (HTS) for discovery of small-molecule allosteric inhibitors of patholog...
An automated, scalable, and rapid AST system for Gonorrhea STIs
Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae (NG) that infects the urogenital, anorectal and pharyngeal tracts in humans. In 20...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project
Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050.To date, though, research on the signs and symptoms of AD...
Defining the cell and molecular basis of Toxoplasma recrudescence
Project Summary Reactivation of toxoplasmosis is a significant health threat to people chronically infected with this parasite and is life-threatening to infected individuals that...
Proteolytic regulation of the Streptococcus pyogenes cell surface
PROJECT SUMMARY/ABSTRACT Streptococcus pyogenes (Spy; group A Streptococcus) is the most prolific pathogen in the number of distinct diseases it is responsible for.Most commonly Sp...
Immunity against fungal infections
PROJECT SUMMARY Despite the global rise in fungal infections, including those by endemic sp ., there is no licensed fungal vaccine available.This is mainly due to poor understandin...
Linking Gene Expression Profiles to Cell Fate in Clostridioides difficile Using Time-Lapse Microscopy
Clostridioides difficile is a spore-forming bacterial pathogen that is the leading cause of healthcare-associated infections in the United States.While C. difficile?s ability to pr...
Sentrin proteases, CRMP2 deSUMOylation, and Chronic Pain
ABSTRACT Chronic pain is a pathological state where sensory neurons become hyperexcitable leading to nociceptive neurotransmission in the absence of a painful stimulus.Genetic and...
Effects of experimental sleep disruption and fragmentation on cerebral Mu-opioid receptor function, Mu-opioid receptor agonist analgesia, and abuse liability.
PROJECT SUMMARY/ABSTRACT The proposed supplement leverages the infrastructure of a parent U01 project (1U01HL150568-01; PI: Michael T.Smith, PhD) to examine the contributions of sl...
The Annual Food Safety and Defense Conference, helps to meet the needs of the overall food service community. The conference andoutreach, will be a tool to improve relationships with industry.
Food Protection Task Force (FPTF) The District of Columbia Department of Health Health Regulation and Licensing Administration Food Safety and Hygiene Inspection ServicesDivision F...
Global Cooperation to Promote Clinical Research in Children
FDA PA 19-306 Project Summary Bierer, Barbara E., M.D.Global Cooperation to Promote Clinical Research in Children Project Summary The Multi-Regional Clinical Trial (MRCT) Center of...
Sociomarkers to Predict Asthma Control and Emergency Room Visits (SPACER)
PROJECT ABSTRACT Asthma impacts more than 25 million adults and children in the U.S. with high associated morbidity and socioeconomic disparities in outcomes. Because effective med...
CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimers Disease
PROJECT SUMMARY/ABSTRACT The apolipoprotein E epsilon 4 (APOE 4) allele is the most important genetic risk factor for late onset Alzheimer's disease (AD). A recent review by...