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201,169 grants found
Showing 197,881 – 197,900 of 201,169 grants
Impact of ANCA Type and Rituximab vs. Cyclophosphamide on Cardiovascular Risk, Mortality, and Quality-Adjusted Life Years inANCA-Associated Vasculitis
Candidate: Zachary S.Wallace, MD is an Instructor in Medicine at Harvard Medical School (HMS) and an Assistant in Medicine in the Rheumatology Unit at Massachusetts General Hospita...
Glioma Circuitry: Bridging Systems Neuroscience and Cancer
Project Summary DP1 NS111132 original summary: High-grade gliomas such as glioblastoma and diffuse intrinsic pontine glioma (DIPG) are among the most intractable human cancers.Thes...
Combining Bacteriophage-Mediated Decolonization with Microbial Engraftment to Foster Sustained Supragingival Microbiome Modulation for Enhanced Anti-Cariogenic Therapy
Vulcan Biologics plans to harness the power of synthetic biology to enable persistent and stable modulation of the oral microbiome for the prevention of dental caries.Caries are ch...
Structure and function of mammalian CPEB2 aggregates in normal and AD brain
Project Summary The aggregate failure of pre-clinical and clinical trials in AD has demonstrated that an improved fundamental understanding of memory and how the molecular componen...
Imaging Bacterial Infections in Vivo: First in Man Studies
Project Summary/Abstract Infection is the major complication of virtually all medical devices. It is estimated that 2 million patients acquire a nosocomial infection in the US ever...
Regulatory clearance of a rehabilitation system for individuals with upper limb loss
ABSTRACT Our work to date has resulted in the development of several technologies focused on improving the lives of individuals with upper-limb loss (ULL). First, our Sense pattern...
Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers
PROJECT ABSTRACT The rate of Alzheimer’s Disease and related dementias (AD/ADRD) is nearly twice as high among African Americans when compared to Whites. African Americans are more...
Identifying best methods for the detection of subtle cognitive decline
PROJECT SUMMARY / ABSTRACT New submission for PAS-19-391 (Small Research Grant Program for the Next Generation of Researchers in AD/ADRD Research: Area of Focus Archiving and Lever...
Improving Care for Nursing Home residents with Diabetes and Cognitive Impairment
Public Health Significance: Nursing home (NH) residents with diabetes and Alzheimer’s disease and related dementias are a large, growing population at high risk for adverse outcome...
Mesodermal Commitment of the Definitive Hematopoietic Program
PROJECT SUMMARY / ABSTRACT The overall goal of our research is to understand the origin, development and regulation of the embryonic progenitor to the hematopoietic stem cell (HSC)...
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Intimate partner violence (IPV), the physical violence, sexual violence, psychological aggression, or stalking by a current or former intimate partner, is a significant public heal...
Regulatory clearance of a rehabilitation system for individuals with upper limb loss
ABSTRACT Our work to date has resulted in the development of several technologies focused on improving the lives of individuals with upper-limb loss (ULL). First, our Sense pattern...
Improving Survey/Cognitive Completions and Home Examination Successes in Wave VI of Add Health
Project Summary Achieving high consent and response rates in nationally-representative longitudinal studies is a pressing scientific issue. Wave VI of the National Longitudinal Stu...
Elucidating the role of microglia and neurotrophin receptor p75 on neuronal degeneration in frontotemporal dementia
Frontotemporal dementia (FTD) comprises a group of early-onset neurodegenerative diseases characterized by widespread neuronal degeneration in the central nervous system leading to...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...
Impairment of ischemia-induced vascular functions by PS1 FAD mutants
Cerebral microvasculature abnormalities, such as degeneration of the capillary endothelium, are implicatedin the genesis of Alzheimer's disease (AD) neuropathology. In additio...
ENIGMA World Aging Center
ABSTRACTOne in three seniors dies with Alzheimer’s disease (AD) or another dementia - diseases that cost the nation $259 billion, to rise to $1.1 trillion by 2050 (Alzheimer’s Asso...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...
Genetic Predictors of Prostate Cancer Survival
Project Summary / Abstract Even though most men diagnosed with prostate cancer will not die of the disease, prostate cancer is still the second leading cause of cancer death among...