Browse All Grants
201,169 grants found
Showing 197,921 – 197,940 of 201,169 grants
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
PROJECT SUMMARY/ABSTRACT Glaucoma affects more than 70 million people worldwide and is the world's leading cause of irreversible blindness. The only current method to delay it...
Impairment of Ischemia-induced Vascular Functions by PS1 FAD Mutants
Cerebral microvasculature abnormalities, such as degeneration of the capillary endothelium, are implicatedin the genesis of Alzheimer's disease (AD) neuropathology. In additio...
Management of Complex Medication Regimens among Older Adults with Alzheimer's Disease and Related Dementias and their Caregivers
PROJECT SUMMARY Alzheimer’s disease and related dementias (ADRD) are progressive diseases characterized by their debilitating impact on cognitive function. Adults ages 65-years and...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory cel...
Localizing and modulating competing memories of fear and safety in the human brain
PROJECT SUMMARY. Pathologies characterized by excessive fear and anxiety are the most common mental illness with a 12-month prevalence estimate of about 40 million American adults....
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
ABSTRACT To infect airway epithelial cells, influenza A virus (IAV) must penetrate the secreted mucus and underlying periciliary layer barriers – both comprised, in large part, of...
Investigating the Effect of Antibody Mediated Feedback on B Cell Clonal Selection
Project Summary/Abstract High affinity antibody titers elicited by infection or vaccination form the basis for protection against reinfection. However, preexisting antigen-specific...
Inhibition of Radiation-Induced Coronary Microvascular Disease
ABSTRACT This application is designed to address the scientific goals of FOA-PA-19-112. Coronary microvascular disease (CMD) is major sequelae of chest radiotherapy in cancer survi...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis
PROJECT SUMMARY/ABSTRACT The overarching goal of my proposal is to acquire technical and professional skills to become an independent investigator at a leading academic institution...
Investigating the Roles of Phospholipase A2s and Diacylglycerol Signaling in Ferroptosis
PROJECT SUMMARY Despite rapid advances in cancer therapeutic development, acquired drug resistance continues to threaten the long-term efficacy of existing chemotherapeutic agents,...
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
ABSTRACT Menopause is an inevitable stage in normal human aging, affecting the quality of life of millions of women all over the world. Menopausal symptoms including hot flushes, s...
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous System
Project Summary/Abstract Intestinal motility is regulated by the Enteric Nervous System (ENS), which resides entirely within the gut wall and comprises the largest collection of ne...
Immunity against fungal infections
PROJECT SUMMARY Despite the global rise in fungal infections, including those by endemic sp ., there is no licensed fungal vaccine available. This is mainly due to poor understandi...
Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers
PROJECT ABSTRACT The rate of Alzheimer’s Disease and related dementias (AD/ADRD) is nearly twice as high among African Americans when compared to Whites. African Americans are more...
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
ABSTRACT Menopause is an inevitable stage in normal human aging, affecting the quality of life of millions of women all over the world. Menopausal symptoms including hot flushes, s...
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertension
PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown tha...
Identification of enteric Juvenile Protective Factors and their role in stimulating neurogenesis in the adult and ageing Enteric Nervous System
Project Summary/Abstract Intestinal motility is regulated by the Enteric Nervous System (ENS), which resides entirely within the gut wall and comprises the largest collection of ne...
Leveraging platelet contraction cytometry for immune thrombocytopenia
PROJECT SUMMARY/ABSTRACT Defined by low platelet count in the absence of any other cause, immune thrombocytopenic purpura (ITP) affects over 4,000 US children and 8,000 adults each...