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201,169 grants found
Showing 197,941 – 197,960 of 201,169 grants
Role of ROCK isoform-mediated actin cytoskeleton modification in the pathogenesis of heart disease
PROJECT ABSTRACT The prevention and treatment of heart disease remain challenging. Rho kinase (also named ROCK) has recently emerged as a potential therapeutic target for various c...
Hypothalamic and metabolic dysfunction in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the most common cause of dementia in the elderly with currently no cure or effective disease-modifying therapy. The pathogenesi...
Insights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseases
PROJECT SUMMARY Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic disease characterized by lipid retention and vascular inflammation. Endothelial cells...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project
Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of A...
SCC-CVIC-PG Track A: Enabling Safe, Community-wide Bike-to-Work Strategies via Participatory Sensing
This university-community collaboration aims to advance the state-of-the-art in active and sustainable mobility for commuters. The project seeks to use innovative ecosystems of sma...
SCC-CIVIC-PG Track A: Leveraging AI-assist Microtransit to Ameliorate Spatiotemporal Mismatch between Housing and Employment
COVID-19 disproportionately affects the low-wage workers whose spatiotemporal mobility pattens, e.g., between housing and job, have dramatically changed. Microtransit service has b...
Increasing the Academic and Career Success of Alaska Native and Rural Students in Science and Math
This project will address the national need for skilled scientists and mathematicians by increasing the recruitment, retention, and graduation of academically talented, low-income...
I-Corps: A Novel Knee Sleeve that Provides Dynamic Motion Restraint to Abnormal Loading
The broader impact/commercial potential of this I-Corps project is the development of evidence-based interventions to reduce the risk of musculoskeletal injury associated with grea...
SCC-CIVIC-PG Track A: Data-driven and Community Engaged Planning Tools For Addressing Spatial Mismatch
To address spatial mismatch, housing agencies seek to locate affordable housing proximate or well-connected to jobs and opportunities. At the same time, transit agencies strive to...
Collaborative Research: Integrating Theory and Experiment to Unravel Protein Transport in the ER
The endoplasmic reticulum, or ER, is a specialized intracellular structure responsible for a myriad of critical cellular functions, including protein synthesis, quality-control, an...
Model Theoretic Classification Theory and Finite Combinatorics
Model theory is a branch of mathematical logic which seeks to understand common structural phenomena driving the behavior of different types of mathematical objects. A crucial idea...
Temporal coordination of transcription, translation, and protein degradation for meiotic termination
This project is focused on the cell division pathway of meiosis, which is crucial for the production of gametes. During meiosis, the genetic material, which is contained in chromos...
Evolutionary modification of AGS protein contributes to micromere formation in sea urchins
Acquisition of a novel developmental program during evolution has been proposed to have important contributions to the diversity of life on earth. This research addresses fundament...
NSFDEB-NERC: Collaborative Research: Wildlife corridors: do they work and who benefits?
In recent years, governments have begun to connect parks and other large natural areas by conserving wildlife corridors – swaths of semi-natural land intended to allow the free flo...
Transitions: Spatiotemporal Behaviors of Metabolic Fluxes in Cell Biology
Metabolism supplies the energy and material that living cells use to grow, move, and establish their internal structure. Metabolic fluxes, the rate of turnover of molecules through...
Collaborative Research: Modeling the Origin and Evolution of Hawaiian Plants
Where we find species living today reflects not only how and when their direct ancestors evolved, but also where they evolved. The inseparable relationship between geological and e...
SCC-CIVIC-PG Track A: MICOPP: Mobility Improvements to achieve transportation equity in Communities through joint Optimization of Public and Private community-based resources
Legacy industrial cities face numerous barriers to creating an equitable transportation system for all residents. Such is the case of Cleveland, Ohio, whose once vibrant public tra...
RAPID: Real-time Forecasting of COVID-19 risk in the USA
In an effort to support decision making by governments and individuals related to the COVID-19 pandemic, the researchers will develop a set of epidemic forecast models to accuratel...
SBIR Phase I: Development of a Novel Biosensor to Accelerate Investigations of COVID-19 and the Gut Microbiome.
The broader impact of this Small Business Innovation Research (SBIR) Phase I project will be advanced understanding of the interaction between SARS-CoV-2, COVID-19, and the human g...
RAPID: Modeling COVID-19 Coronavirus Vaccine and Nursing Homes
Nursing Homes (NHs) have been hit particularly hard by the COVID-19 coronavirus pandemic, with NH residents accounting for nearly a quarter of all COVID-19 deaths. This project wil...