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201,169 grants found
Showing 197,961 – 197,980 of 201,169 grants
Collaborative research: The Intergenerational Effects of the COVID-19 Pandemic
This project examines the effects of COVID-19 exposure during pregnancy on birth outcomes, over time, and across different groups defined by different sources of disadvantage.The C...
Helping Earth and Environmental Science Programs in Changing Times: Virtual Traveling Workshops and Expanding the Conversation about Diversity, Equity and Inclusion
All of education is transitioning to increased reliance on virtual formats. Distance education pre-dates the internet but has had to accelerate to near-ubiquity since the COVID-19...
Improving Care for Nursing Home residents with Diabetes and Cognitive Impairment
Public Health Significance: Nursing home (NH) residents with diabetes and Alzheimer?s disease and related dementias are a large, growing population at high risk for adverse outcome...
Me & You-Tech: A socio-ecological solution to teen dating violence for the digital age.
ABSTRACT The goal of this 3-year Fast-Track STTR is to develop and evaluate a multi-level (youth, parent, school) Internet-based dating violence (DV) prevention program, ?Me &...
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
Abstract Total pancreatectomy with islet autotransplant (TPIAT) is performed to treat the severe, intractable pain of chronic pancreatitis for patients who have failed medical or e...
Synergistic microglial activation and tumor cell killing for improved GBM response
PROJECT SUMMARY/ABSTRACT Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults.Current therapies remain unsuccessful in improving overall survival; thu...
Anti-CV2 autoantibodies unmask a CRMP5/GluN2B pain signaling hub
Abstract Neuropathic pain is common neurological disorder affecting between 5-10% of the general population and predicted to become more common in the future because of the aging p...
Molecular mechanisms underlying cortical interneuron synaptic specificity
Project Summary/Abstract Cortical inhibitory GABAergic interneurons (INs), which develop intricate local circuits, critically regulate higher- order brain functions by balancing an...
Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults
OTHER PROJECT INFORMATION ?Project Summary/Abstract Labor Market Conditions and the Quality of Long-Term Care Provided to Older Adults The rapid aging of the U.S. population, with...
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients.An example is a type of blood cancer, kno...
Application of Advanced Quantitative Methods to Schizophrenia Research
PROJECT SUMMARY Abnormalities of white matter are important in schizophrenia. A preponderance of studies have found decreased levels of transcripts for myelin-related proteins in a...
Brain-selective estrogen therapy for menopausal hot flushes in an advanced translational animal model
ABSTRACT Menopause is an inevitable stage in normal human aging, affecting the quality of life of millions of women all over the world.Menopausal symptoms including hot flushes, sl...
Sociomarkers to Predict Asthma Control and Emergency Room Visits (SPACER)
PROJECT ABSTRACT Asthma impacts more than 25 million adults and children in the U.S. with high associated morbidity and socioeconomic disparities in outcomes.Because effective medi...
Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device
Project Summary: Noninvasive transcranial detection of intracranial hemorrhage using a tri-coil handheld portable eddy current damping imaging device Stroke and traumatic brain inj...
Management of Complex Medication Regimens among Older Adults with Alzheimer's Disease and Related Dementias and their Caregivers
PROJECT SUMMARY Alzheimer?s disease and related dementias (ADRD) are progressive diseases characterized by their debilitating impact on cognitive function.Adults ages 65-years and...
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertension
PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown tha...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory cel...
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Statement of Work A study coordinator is being hired for the current R01 award and was originally budgeted for 35 hrs/week. For the supplement we will increase this to 40 hrs/week...
The Progressive Elevation of Spontaneous Cortical Activity in HAND (PESCAH) Project
Project Summary/Abstract It is well known that human cortical neurons exhibit spontaneous firing in the absence of incoming exogenous and endogenous input. Across a neuronal popula...
Molecular mechanisms underlying cortical interneuron synaptic specificity
Project Summary/Abstract Cortical inhibitory GABAergic interneurons (INs), which develop intricate local circuits, critically regulate higher- order brain functions by balancing an...