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201,169 grants found
Showing 197,981 – 198,000 of 201,169 grants
Genetic Predictors of Prostate Cancer Survival
Prostate cancer (PC) has a very heterogenous clinical course. Many men have an indolent PC that can be safely watched for years without progression. Alternatively, other men have a...
Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity
PROJECT SUMMARY / ABSTRACT Staphylococcus epidermidis is a ubiquitous member of the human skin and mucosal microbiota. Functionally, it is a key contributor to human health via imm...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Imaging Bacterial Infections in Vivo: First in Man Studies
Project Summary/Abstract Infection is the major complication of virtually all medical devices. It is estimated that 2 million patients acquire a nosocomial infection in the US ever...
Role of the Intestinal Microbiota in ALS
PROJECT SUMMARY ALS is a neurodegenerative disease affecting motor neurons with limited treatment options and a median survival of 3-5-years. We submit a significantly revised prop...
Identifying the Cognitive, Psychological, and Neuroimaging Signatures of Head Trauma in Female Survivors of Intimate Partner Violence
Intimate partner violence (IPV), the physical violence, sexual violence, psychological aggression, or stalking by a current or former intimate partner, is a significant public heal...
Genetic predictors of prostate cancer survival
PROJECT SUMMARY/ABSTRACT The underlying scientific premise of the parent grant is that the risk factors and mechanisms that drive prostate cancer development likely differ from tho...
Understanding Individual Differences in Working Memory Training and Transfer in Older Adults at Risk of Alzheimer's Disease and Related Dementias
PROJECT SUMMARY The overall objective of the proposed work is to understand factors mediating and moderating transfer of learning in the context of training Working Memory (WM) sys...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug targets a...
Add Health as a Resource for the Science of the Exposome and Risk for AD/ADRD
Project Summary This supplement to U01 AG071450 responds to NOT-AG-22-022, which lays out the “urgent need for research infrastructure that addresses the role of diverse physical,...
Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis
PROJECT SUMMARY/ABSTRACT The overarching goal of my proposal is to acquire technical and professional skills to become an independent investigator at a leading academic institution...
Personalized Dietary Management in Type 2 Diabetes
Abstract Hyperglycemia in type 2 diabetes (T2D) is associated with a variety of vascular complications of the disease, but clinical trials of medication regimens designed to achiev...
Improving risk prediction of adverse outcomes in hemodialysis patients by incorporating non-traditional risk factors
PROJECT SUMMARY: Candidate: The primary objective of this application is to support Dr. Lili Chan's career development into an independently funded clinical investigator lever...
The Role of Enteric Infection in Flares of Inflammatory Bowel Disease
PROJECT SUMMARY AND ABSTRACT Inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic, progressive, inflammatory conditions...
CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
Project Summary/Abstract The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central mediator of two opposing forms of NMDA- receptor (NMDAR)-dependent synaptic plasticit...
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
Project Summary Title: Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning Summa...
Sociomarkers to Predict Asthma Control and Emergency Room Visits (SPACER)
PROJECT ABSTRACT Asthma impacts more than 25 million adults and children in the U.S. with high associated morbidity and socioeconomic disparities in outcomes. Because effective med...
Engineering a novel biomaterial for oxygen transport applications
Abstract Hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant c...
Single cell, whole genome analysis of the aging human cardiomyocyte
Project Summary/Abstract Recent evidence suggests that environmental factors causing somatic mutations during the lifetime have a more crucial role, not only in cancer but also in...
Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers
This is a K01 award application for Dr. Jacqueline Eaton, a gerontologist and young investigator pursuing transdisciplinary research on enhancing the quality of life of older adult...