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201,169 grants found
Showing 198,021 – 198,040 of 201,169 grants
Sptlc3-derived sphingolipids in cardiomyocyte death in ischemia
Project Summary Ischemic cardiomyopathy is the leading cause of death in the world and affects approximately 1% to 2% of the general population. Sphingolipids including ceramides a...
Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury
PROJECT SUMMARY / ABSTRACT Lung failure from endotoxemia and sepsis induces widespread and often rapid lung vascular endothelial injury due to unfettered influx of inflammatory cel...
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertension
PROJECT SUMMARY WENCESLAU, CAMILLA F. One of the major pathophysiological characteristics of hypertension is the presence of vascular remodeling. Accordingly, it has been shown tha...
Dorsal striatal phosphodiesterase 10A and compulsive ethanol use
ABSTRACT Alcohol use disorder (AUD) is a chronic, relapsing disorder that afflicts 29% of Americans in their lifetime1,2, is disabling2 and increases mortality3. New drug targets a...
BP-ENDURE at the University of Nevada
The University of Nevada, Reno (UNR) proposes to increase the number of well-trained, highly qualified neuroscientists from underrepresented populations. Accelerating the research...
A Mechanistic Study to elucidate the role of Protein S in elevating the risk of Thrombosis in Obese, Pre-menopausal women
Protein S (PS) is a unique protein because it functions non-enzymatically as an anticoagulant, and because it interacts with plasma components that function in both hemostasis and...
An automated, scalable, and rapid AST system for Gonorrhea STIs
Gonorrhea is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae (NG) that infects the urogenital, anorectal and pharyngeal tracts in humans. In 20...
National Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia Project
Project Summary Alzheimer's Disease and Related Dementias (ADRD) are projected to affect 14 million Americans by 2050. To date, though, research on the signs and symptoms of A...
Management of Complex Medication Regimens among Older Adults with Alzheimer's Disease and Related Dementias and their Caregivers
PROJECT SUMMARY Alzheimer’s disease and related dementias (ADRD) are progressive diseases characterized by their debilitating impact on cognitive function. Adults ages 65-years and...
Inhibition of Radiation-Induced Coronary Microvascular Disease
ABSTRACT This application is designed to address the scientific goals of FOA-PA-19-112. Coronary microvascular disease (CMD) is major sequelae of chest radiotherapy in cancer survi...
Impairment of ischemia-induced vascular functions by PS1 FAD mutants
Cerebral microvasculature abnormalities, such as degeneration of the capillary endothelium, are implicatedin the genesis of Alzheimer's disease (AD) neuropathology. In additio...
Engineering a novel biomaterial for oxygen transport applications
Abstract Hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant c...
Hypothalamic and metabolic dysfunction in Alzheimer's disease
PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the most common cause of dementia in the elderly with currently no cure or effective disease-modifying therapy. The pathogenesi...
UAB Research in Aging through Mentorship and Practice - Undergraduate Program (UAB RAMP-UP)
Despite efforts to increase the number of underrepresented researchers in universities across the country, there is a continued lack of diversity in Aging Research. The goal of the...
Single cell, whole genome analysis of the aging human cardiomyocyte
Project Summary/Abstract Recent evidence suggests that environmental factors causing somatic mutations during the lifetime have a more crucial role, not only in cancer but also in...
Reducing maternal prenatal depression to improve child cardiovascular health
PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors acros...
Osteopontin: A Novel Mediator of prostatic inflammation and fibrosis
PROJECT SUMMARY/ABSTRACT The overarching goal of my proposal is to acquire technical and professional skills to become an independent investigator at a leading academic institution...
Investigation of Mechanosensory Signaling in the Pathogenesis of Traumatic Brain Injury in Human iPSC-derived Cortical Brain Organoids
Project Summary/Abstract Global incidence of Traumatic Brain Injury (TBI) is on the rise, particularly among athletes, military personnel, and elderly citizens1. TBI represents a s...
Leveraging platelet contraction cytometry for immune thrombocytopenia
PROJECT SUMMARY/ABSTRACT Defined by low platelet count in the absence of any other cause, immune thrombocytopenic purpura (ITP) affects over 4,000 US children and 8,000 adults each...
iGLAMOUR Study: Innovations in Glaucoma Adherence and monitoring Of Under-Represented minorities
PROJECT SUMMARY/ABSTRACT Glaucoma affects more than 70 million people worldwide and is the world's leading cause of irreversible blindness. The only current method to delay it...