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201,169 grants found
Showing 198,041 – 198,060 of 201,169 grants
Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Project Summary In some cancers, intriguingly, the same mutation results in drastically different disease phenotypes in different patients. An example is a type of blood cancer, kn...
Developing and Testing the Enhancing Active Caregiver Training (EnACT) Intervention for Dementia Family Caregivers
This is a K01 award application for Dr. Jacqueline Eaton, a gerontologist and young investigator pursuing transdisciplinary research on enhancing the quality of life of older adult...
Association of Perceived Stress and Cognition
Project/Summary Abstract African Americans are twice as likely to develop Alzheimer's disease (AD) as Whites, but few studies have focused on these cognitive disparities and r...
SCC-CIVIC-PG Track B: Remote Monitoring of Small Rural Water Systems to Ensure Safe Drinking Water through Disasters and Natural Recovery
More than 45,000 community water systems in the US are small, each providing water to up to 10,000 people. These systems, which provide a vital supply of potable water to mostly ru...
Increasing the Recruitment, Retention, and Graduation of STEM Undergraduate Student, with Emphasis on First-Generation College Students
This project will contribute to the national need for skilled scientists, engineers, and technicians by supporting the retention and graduation of high-achieving, low-income studen...
SBIR Phase I: Hypothalamus Stem Cell Exosomes for Treatment of COVID-19 (COVID-19)
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to create a novel type of therapeutic using cutting-edge technology and...
I-Corps: Comprehensive tool to capture spatio-temporal variations in social media health risk communication for COVID-19 and other health risks
The broader impact/commercial potential of this I-Corps project is the development of a software platform that may be integrated into crisis management systems such as public healt...
SBIR Phase I: Rapid repurposing and translation of COVID-19 therapeutics using a AI-based biosimulation platform: application to ACE2 and Ca2+ multi-target therapies (COVID-19)
The broader impact of this SBIR Phase I project is to provide immediate positive outcomes in the COVID-19 therapeutics. The platform will use artificial intelligence (AI) to develo...
SCC-CIVIC-PG Track B: Co-Designing Protocols for Data Creation, Analysis, and Use among Local Care Networks in Seattle and Boston to Enhance Disaster Resilience
Crises catalyze existing and latent groups of people to engage in collective action - asking individuals to pool their undivided attention, unique skills, and valuable informationa...
SCC-CIVIC-PG Track B: Equitable Food-Security: Disaster-resilient supply chains for pandemics and extreme weather events
Food insecurity is the lack of consistent and reliable access to nutritious food needed for an active, healthy life. It is a significant problem in Harris County, Texas, where over...
Near-IR Ratiometric Fluorescence Probes for Assessing Cargo Delivery to Prostate Tumors
PROJECT SUMMARY/ABSTRACT Prostate-specific membrane antigen (PSMA) is the hallmark enzyme-biomarker for prostate cancer because it is expressed in the epithelium of nearly all pros...
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy. A...
Projection Specific Modulation of Neural Activity with A Non-genetic Method
Project Summary In psychiatry and neurology, there are many debilitating disorders based on aberrant circuits for which we do not have adequate treatment methods.Recent development...
Near-IR Ratiometric Fluorescence Probes for Assessing Cargo Delivery to Prostate Tumors
PROJECT SUMMARY/ABSTRACT Prostate-specific membrane antigen (PSMA) is the hallmark enzyme-biomarker for prostate cancer because it is expressed in the epithelium of nearly all pros...
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy. A...
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy. A...
Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer
Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy. A...
Controllable 2- and 3D Assembly of Mechanically Robust Skin Tissue Via Long Term Expression of DNA on Cell Membranes
The proposed research plan will develop innovative bioconjugation and DNA-mediated cell assembly strategies for rapid creation of self-assembled multicellular scaffolds with progra...
Investigating the role of Eya3 in the regulation of innate immune signaling cascades in Triple Negative Breast Cancer
PROJECT SUMMARY/ABSTRACT: Triple Negative Breast Cancer (TNBC) is a subtype of breast cancer characterized by low or absent expression of the estrogen receptor and the HER2 growth...
An Engineered Nanocarrier Platform for Enhancing Immune Responses to Neoantigen-Targeted Cancer Vaccines
Project Summary Vaccines targeting cancer neoantigens have the potential to enhance the magnitude, function, and duration of an anti-tumor T cell response, offering a promising str...