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201,169 grants found
Showing 198,081 – 198,100 of 201,169 grants
RNA tools for probing spliceosome dynamics
Project Summary/Abstract Alternative splicing is a central mechanism to diversify genetic information on the post-transcriptional level.Advances in sequencing technologies revealed...
Damage-Associated Molecular Patterns Driving Fibrosis Progression in Scleroderma
June 3 2018 ABSTRACT Synchronous fibrosis in multiple organs is the defining hallmark of systemic sclerosis (SSc), but its pathogenesis remains poorly understood, and there is an u...
Inflammation, Social Networks, and Depression in Rural Uganda
PROJECT SUMMARY Major depressive disorder is one of the top 5 contributors to years lived with disability among adults in sub- Saharan Africa. Numerous studies have suggested a lin...
RNA tools for probing spliceosome dynamics
Project Summary/Abstract Alternative splicing is a central mechanism to diversify genetic information on the post-transcriptional level. Advances in sequencing technologies reveale...
mHealth Facilitated Intervention to Improve Medication Adherence among Persons Living with HIV
There are more than a million persons living with HIV in the United States. Despite the effectiveness of antiretroviral therapy (ART), viral suppression, particularly durable viral...
Investigating the role of Eya3 in the regulation of innate immune signaling cascades in Triple Negative Breast Cancer
PROJECT SUMMARY/ABSTRACT: Triple Negative Breast Cancer (TNBC) is a subtype of breast cancer characterized by low or absent expression of the estrogen receptor and the HER2 growth...
An Engineered Nanocarrier Platform for Enhancing Immune Responses to Neoantigen-Targeted Cancer Vaccines
Project Summary Vaccines targeting cancer neoantigens have the potential to enhance the magnitude, function, and duration of an anti-tumor T cell response, offering a promising str...
Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk
PROJECT SUMMARY/ABSTRACT Ovarian cancer (OC) is the eleventh most common cancer and fifth deadliest among U.S. women. The low incidence, high fatality and molecularly broad range o...
Altering Cardiac Cell Fate for Heart Repair
Abstract Direct cardiac reprogramming holds great promise as a novel therapy for heart failure, a common and morbid disease that is usually caused by irreversible loss of massive f...
Damage-Associated Molecular Patterns Driving Fibrosis Progression in Scleroderma
June 3 2018 ABSTRACT Synchronous fibrosis in multiple organs is the defining hallmark of systemic sclerosis (SSc), but its pathogenesis remains poorly understood, and there is an u...
Rational translation of gold nanoparticle mediated radiosensitization to the clinic
The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (GN...
Altering Cardiac Cell Fate for Heart Repair
Abstract Direct cardiac reprogramming holds great promise as a novel therapy for heart failure, a common and morbid disease that is usually caused by irreversible loss of massive f...
mHealth Facilitated Intervention to Improve Medication Adherence among Persons Living with HIV
There are more than a million persons living with HIV in the United States. Despite the effectiveness of antiretroviral therapy (ART), viral suppression, particularly durable viral...
Rational translation of gold nanoparticle mediated radiosensitization to the clinic
The use of high atomic number (Z) elements as radiosensitizers of tumors has been well documented in the literature over the last few decades. In particular, gold nanoparticles (GN...
RADX TECH PROJECT, L3 HEALTHCARE, LLC: RADX PERFORMANCE EVALUATION OF YUKON SWABS
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) has an open solicitation for proposals to provide up to $500 million across multiple projects to rapidly pro...
Molecular Functions of CDK1 in Gastric Tumorigenesis
ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide. The 2018 global cancer statistics report indicates an estimated over 1,000,000 new ca...
Molecular Imaging of persistent HIV: CD30
PROJECT SUMMARY: A major hurdle to HIV eradication is the presence of infected cells that persist despite suppressive antiretroviral therapy (ART). HIV largely resides outside of t...
Organizational and Cultural Dynamics in Genomics Companies: Industry Engagement in Navigating Social and Ethical Issues
This K99/R00 Award is designed to generate scholarship and interventions to guide genomics companies towards more just practices. It does so through a five-year training and resear...
Molecular Functions of CDK1 in Gastric Tumorigenesis
ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide.The 2018 global cancer statistics report indicates an estimated over 1,000,000 new cas...
Deciphering Mechanisms of Mitochondrial Extrusion
Protein aggregation and mitochondrial dysfunction are key factors in aging and in neurodegenerative disease, like Alzheimer?s disease.It is clear that full understanding of mechani...