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201,169 grants found
Showing 198,101 – 198,120 of 201,169 grants
The role of differential bone marrow immune landscape in permissive tumor growth in the spine
PROJECT SUMMARY/ABSTRACT Roughly 400,000 people in the U.S. have bone metastases, the vast majority occurring in the spine. Metastases to the spine results in fractures, pain, para...
Genetic and functional assessment of human-specific duplicated genes
PROJECT SUMMARY Recent advances in sequencing technologies and bioinformatics have created an emerging picture of structurally dynamic human and non-human primate genomes.In additi...
Molecular Imaging of persistent HIV: CD30
PROJECT SUMMARY: A major hurdle to HIV eradication is the presence of infected cells that persist despite suppressive antiretroviral therapy (ART).HIV largely resides outside of th...
Organizational and Cultural Dynamics in Genomics Companies: Industry Engagement in Navigating Social and Ethical Issues
This K99/R00 Award is designed to generate scholarship and interventions to guide genomics companies towards more just practices.It does so through a five-year training and researc...
The role of differential bone marrow immune landscape in permissive tumor growth in the spine
PROJECT SUMMARY/ABSTRACT Roughly 400,000 people in the U.S. have bone metastases, the vast majority occurring in the spine. Metastases to the spine results in fractures, pain, para...
Genetic and functional assessment of human-specific duplicated genes
PROJECT SUMMARY Recent advances in sequencing technologies and bioinformatics have created an emerging picture of structurally dynamic human and non-human primate genomes. In addit...
Deciphering Mechanisms of Mitochondrial Extrusion
Protein aggregation and mitochondrial dysfunction are key factors in aging and in neurodegenerative disease, like Alzheimer’s disease. It is clear that full understanding of mechan...
Organizational and Cultural Dynamics in Genomics Companies: Industry Engagement in Navigating Social and Ethical Issues
This K99/R00 Award is designed to generate scholarship and interventions to guide genomics companies towards more just practices. It does so through a five-year training and resear...
Molecular Functions of CDK1 in Gastric Tumorigenesis
ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide. The 2018 global cancer statistics report indicates an estimated over 1,000,000 new ca...
Molecular Functions of CDK1 in Gastric Tumorigenesis
ABSTRACT/SUMMARY: Gastric cancer is the third leading cause of cancer-related death worldwide. The 2018 global cancer statistics report indicates an estimated over 1,000,000 new ca...
Project I - Transcriptomic Analysis of Structural Birth Defects in Mouse Developmental Mutants
PROJECT SUMMARY In this project we plan to apply a powerful and scaleable technique of combinatorial indexing to characterize gene expression at the single-cell level in mice carry...
Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects
PROJECT SUMMARY The unifying theme of this proposal is the aim to use state-of-the-art technologies to investigate the basic biology of mammalian organ development and human struct...
CORE A - Administrative Core
PROJECT SUMMARY The Administrative Core will coordinate the administrative, fiscal, and organization aspects of our PPG program. Personnel in this Core will facilitate scientific c...
Project I - Transcriptomic Analysis of Structural Birth Defects in Mouse Developmental Mutants
PROJECT SUMMARY In this project we plan to apply a powerful and scaleable technique of combinatorial indexing to characterize gene expression at the single-cell level in mice carry...
Project II - 3D Quantitative Analysis of Mouse Models of Structural Birth Defects Through Computational Anatomy
PROJECT SUMMARY E15.5 fetuses of 6 homozygous mutants from each of the 85 sci-RNA-seq lines will be acquired from Project 1 to be imaged via high-resolution microCT following estab...
Project III - Comprehensive Genomic Evaluation of Structural Birth Defects
PROJECT SUMMARY Structural birth defects (SBD) affect 3-6% of live births and are a leading cause of infant morbidity and mortality worldwide. Most SBD are isolated, occur in the f...
Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance
Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance PROJECT SUMMARY Vaccines face tougher safety standards than most pharmaceutica...
Adaptation and optimization of the Friendship Bench mental health intervention for adolescent girls and young women in South African PrEP delivery settings
ABSTRACT The goal of the proposed K99/R00 award is to support Dr. Jennifer Velloza’s development into an independent HIV and mental health researcher, with a focus on improving del...
Elucidating the Function of LRP1 in APOE-mediated Suppression of Melanoma Metastasis
PROJECT SUMMARY/ABSTRACT Metastatic melanoma is the cause of over 80% of skin cancer deaths. Previous work in our lab interrogating the molecular differences between highly and poo...
Adaptation and optimization of the Friendship Bench mental health intervention for adolescent girls and young women in South African PrEP delivery settings
ABSTRACT The goal of the proposed K99/R00 award is to support Dr. Jennifer Velloza’s development into an independent HIV and mental health researcher, with a focus on improving del...