Browse All Grants
201,169 grants found
Showing 198,141 – 198,160 of 201,169 grants
CORE A - Administrative Core
PROJECT SUMMARY The Administrative Core will coordinate the administrative, fiscal, and organization aspects of our PPG program.Personnel in this Core will facilitate scientific co...
Project II - 3D Quantitative Analysis of Mouse Models of Structural Birth Defects Through Computational Anatomy
PROJECT SUMMARY E15.5 fetuses of 6 homozygous mutants from each of the 85 sci-RNA-seq lines will be acquired from Project 1 to be imaged via high-resolution microCT following estab...
Project III - Comprehensive Genomic Evaluation of Structural Birth Defects
PROJECT SUMMARY Structural birth defects (SBD) affect 3-6% of live births and are a leading cause of infant morbidity and mortality worldwide.Most SBD are isolated, occur in the fi...
Furopyrimidines as novel inhibitors of henipaviruses
The emergence and reemergence of pathogenic viruses represent continuous infectious disease threats to public health. Among these, the paramyxoviruses, which include many important...
Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries
Project Summary More than half a million patients, including children, have benefitted from the remarkable technological breakthrough that are cochlear implants (CI). An increasing...
Neural Mechanisms of Mindfulness-Based Stress Reduction in Adults with Autism Spectrum Disorder
Project Summary/Abstract Adults with autism spectrum disorder (ASD) suffer from depression at up to four times the rate of the general population. Mindfulness-Based Stress Reductio...
Project I - Transcriptomic Analysis of Structural Birth Defects in Mouse Developmental Mutants
PROJECT SUMMARY In this project we plan to apply a powerful and scaleable technique of combinatorial indexing to characterize gene expression at the single-cell level in mice carry...
Project II - 3D Quantitative Analysis of Mouse Models of Structural Birth Defects Through Computational Anatomy
PROJECT SUMMARY E15.5 fetuses of 6 homozygous mutants from each of the 85 sci-RNA-seq lines will be acquired from Project 1 to be imaged via high-resolution microCT following estab...
Project III - Comprehensive Genomic Evaluation of Structural Birth Defects
PROJECT SUMMARY Structural birth defects (SBD) affect 3-6% of live births and are a leading cause of infant morbidity and mortality worldwide. Most SBD are isolated, occur in the f...
Adaptation and optimization of the Friendship Bench mental health intervention for adolescent girls and young women in South African PrEP delivery settings
ABSTRACT African adolescent girls and young women (AGYW) face high rates of HIV and common mental disorders. HIV pre-exposure prophylaxis (PrEP) is a highly effective HIV preventio...
Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance
Incorporation of multilevel ontologies of adverse events and vaccines for vaccine safety surveillance PROJECT SUMMARY Vaccines face tougher safety standards than most pharmaceutica...
Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries
Project Summary More than half a million patients, including children, have benefitted from the remarkable technological breakthrough that are cochlear implants (CI). An increasing...
Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects
PROJECT SUMMARY The unifying theme of this proposal is the aim to use state-of-the-art technologies to investigate the basic biology of mammalian organ development and human struct...
CORE A - Administrative Core
PROJECT SUMMARY The Administrative Core will coordinate the administrative, fiscal, and organization aspects of our PPG program. Personnel in this Core will facilitate scientific c...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the ?-globin gene, resulting in altered red...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the β-globin gene, resulting in altered red...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the β-globin gene, resulting in altered red...
Biased PAR1 Agonism in Sickle Cell Disease
PROJECT SUMMARY Title: Biased PAR1 Agonism in Sickle Cell Disease Sickle cell disease (SCD) is caused by a single nucleotide mutation in the β-globin gene, resulting in altered red...
Inhalation Repurposing of An Approved Drug to Treat Severe Asthma
Project Summary The business objective of Aeon Respire, and the purpose of this SBIR Project, is to execute key steps towards repurposing niclosamide as a new asthma treatment.The...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis.The disru...