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201,169 grants found
Showing 198,161 – 198,180 of 201,169 grants
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
Inhalation Repurposing of An Approved Drug to Treat Severe Asthma
Project Summary The business objective of Aeon Respire, and the purpose of this SBIR Project, is to execute key steps towards repurposing niclosamide as a new asthma treatment. The...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
Inhalation Repurposing of An Approved Drug to Treat Severe Asthma
Project Summary The business objective of Aeon Respire, and the purpose of this SBIR Project, is to execute key steps towards repurposing niclosamide as a new asthma treatment. The...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies.
Summary - A fundamental theme in personalized cancer medicine is to identify specific subgroups of patients, based on molecular biomarkers and/or tumor signatures, which will subse...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
MnSOD-K68-Ac reprograms a lineage plasticity switch / stemness in ER+ breast malignancies
SUMMARY The dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an established hallmark of cancer and an early event in tumorigenesis. The disr...
A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart
Project Summary/Abstract Loss of cardiomyocytes by apoptosis and/or necrosis is a hallmark of cardiac ischemic injury, pathological remodeling, and end-stage heart failure.Although...
Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure
Heart failure (HF) is the most common reason for hospitalization and death among those older than 65-years, and statistic is projected to grow as our population ages. The socioecon...
A microbiome-dependent bile acid metabolite improves type 2 diabetes.
Project Summary/Abstract The molecular mechanisms that explain the potent anti-diabetic effects of bariatric surgery remain elusive.The rapid nature of type 2 diabetes mellitus (T2...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
A Glucocorticoid Receptor-SETDB2 Co-Regulated Liver Metabolic Gene Program
Excess glucocorticoids contribute to the development of diabetes and metabolic syndrome, which includes: obesity, hyperglycemia, hypercholesterolemia, insulin resistance, and liver...
Understanding biased agonism in receptor tyrosine kinases to devise new modalities for their targeting in cancer
PROJECT SUMMARY/ABSTRACT This project takes a unique dynamic view of signaling by receptor tyrosine kinases (RTKs), testing the hypothesis that signaling specificity is kinetically...
Novel dual-targeted inhibitors of EGFR and aurora kinase for lung cancer
PROJECT SUMMARY Small molecule EGFR inhibitors constitute the recommended therapy for EGFR-positive non-small cell lung cancer (NSCLC).Resistance was first reported to EGFR inhibit...
Social Networks of Diffusion and Adoption: Investigating the Network Effects on implementation of evidence-based interventions for early intervention providers of children
Early interventions for preschoolers with Autism Spectrum Disorder (ASD) can result in substantial improvements across cognitive and communication outcomes.1 However, treatment res...
Supporting Personalized Decision Making for Breast Cancer Screening among Older Women
PROJECT SUMMARY/ABSTRACT In the United States, approximately half of women 75 and older undergo screening mammography.Despite widespread use, the benefits of mammography in this ag...
Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1
MASSI/ BOSCO ?ABSTRACT Profilin-1 (PFN1) is a 15kDa actin-binding protein that plays a critical role in regulating cytoskeletal dynamics. In order to promote actin polymerization i...
Longitudinal Antibody Profiles Correlated with Protection from Malaria in Malawi
PROJECT SUMMARY Malaria continues to be responsible for substantial childhood mortality in Africa despite current control efforts.Developing an effective vaccine for malaria elimin...
Intratumor co-delivery of DNA and RNA to relieve cancer pain
Oral cancer causes more prevalent and severe pain than any other cancer.Oral cancer patients suffer from severe, chronic, mechanically-induced pain; talking and eating are profound...
Advancing Drug Development in AL Amyloidosis: Capitalizing Natural History and Assessing Endpoints
Project Summary Amyloidosis Research Consortium (ARC), a 501(c)(3) nonprofit organization focused on accelerating the development, approval, and access to new and innovative treatm...