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201,169 grants found
Showing 198,201 – 198,220 of 201,169 grants
A microbiome-dependent bile acid metabolite improves type 2 diabetes.
Project Summary/Abstract The molecular mechanisms that explain the potent anti-diabetic effects of bariatric surgery remain elusive. The rapid nature of type 2 diabetes mellitus (T...
Impact of ALS-linked mutations on the structure, dynamics and function of profilin-1
MASSI/ BOSCO – ABSTRACT Profilin-1 (PFN1) is a 15kDa actin-binding protein that plays a critical role in regulating cytoskeletal dynamics. In order to promote actin polymerization...
Supporting Personalized Decision Making for Breast Cancer Screening among Older Women
PROJECT SUMMARY/ABSTRACT In the United States, approximately half of women 75 and older undergo screening mammography. Despite widespread use, the benefits of mammography in this a...
A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart
Project Summary/Abstract Loss of cardiomyocytes by apoptosis and/or necrosis is a hallmark of cardiac ischemic injury, pathological remodeling, and end-stage heart failure. Althoug...
Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure
Heart failure (HF) is the most common reason for hospitalization and death among those older than 65-years, and statistic is projected to grow as our population ages. The socioecon...
Intratumor co-delivery of DNA and RNA to relieve cancer pain
Oral cancer causes more prevalent and severe pain than any other cancer. Oral cancer patients suffer from severe, chronic, mechanically-induced pain; talking and eating are profoun...
A Glucocorticoid Receptor-SETDB2 Co-Regulated Liver Metabolic Gene Program
Excess glucocorticoids contribute to the development of diabetes and metabolic syndrome, which includes: obesity, hyperglycemia, hypercholesterolemia, insulin resistance, and liver...
A microbiome-dependent bile acid metabolite improves type 2 diabetes.
Project Summary/Abstract The molecular mechanisms that explain the potent anti-diabetic effects of bariatric surgery remain elusive. The rapid nature of type 2 diabetes mellitus (T...
High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells
Liquid biopsies are poised to revolutionize cancer therapies, by enabling frequent blood-based monitoring of tumor-derived materials, as cancers evolve in response to therapeutic i...
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year.Despite the heterogeneity of the cau...
N-methyl-D-aspartate receptors (NMDAr) participates in renal hemodynamic regulation and blood pressure homeostasis
Abstract Internationally, hypertension is the leading single risk factor for mortality. However, in more than 90% of hypertensive patients, the cause is unknown.There is a critical...
Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne Cardiomyopathy
PROJECT SUMMARY Cardiovascular disease is the primary cause of death for patients with Duchenne muscular dystrophy (DMD). Arrhythmia and cardiac fibrosis leading to dilated cardiom...
Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
ABSTRACT Primary aldosteronism (PA) is the most common adrenal disorder and the most common cause of endocrine hypertension.PA is associated with cardiovascular morbidity and morta...
Functional roles of lymphatics in organogenesis and tissue repair
SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies to...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Translational Studies of the Short-Chain Fatty Acid Acetate for Improving Age-Associated Arterial Dysfunction
PROJECT SUMMARY/ABSTRACT The purpose of this K99/R00 application is to provide support for Dr. Vienna Brunt, a promising postdoctoral fellow in the laboratory of Dr.Douglas Seals,...
Proposed roles of KCNQ2 Channels in Respiratory Homeostasis
PROJECT SUMMARY/ABSTRACT KCNQ channels are key determinants of neuronal activity, and recent clinical evidence identifies mutations in KCNQ2 as a cause of neonatal epileptic enceph...
Investigating multifactorial beta-catenin activation in hepatocellular cancers
Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and lacks molecular- targeted therapies. Activation of Wnt/?-catenin cascade has been...
Chromatin Organization in Glioma Initiation
Project Summary Glioma is the most common primary brain tumor and represents a disproportionate percentage of cancer fatalities in relation to its incidence.In the last decade, it...
Antibody Profiles and Genetics of Pernio-Like Lesions during the COVID-19 pandemic
A subset of patients with coronavirus disease-2019 (COVID-19) develop cutaneous manifestations of their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, incl...