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201,169 grants found
Showing 198,221 – 198,240 of 201,169 grants
Novel Vector Platform for Gene Therapy
ABSTRACT Inherited serum deficiency disorders, such as hemophilia and ?1-antitrypsin (AAT) deficiency, have been considered ideal candidates for corrective gene therapy.In this reg...
Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center
Modified Project Summary/Abstract Section This innovative integrated systems biology application seeks to delineate the complex host/pathogen interactions occurring at the alveolar...
BIOLOGICAL TESTING FACILITY – "QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP
Within the Division of Intramural Population Health Research (DIPHR), the Contraceptive Development Program (CDP) at NICHD supports research and development of compounds that can d...
BIOLOGICAL TESTING FACILITY - "CONTRACEPTIVE TARGET WEB APPLICATIONS
One major obstacle in early phase non-steroidal contraceptive discovery and development is limited by known targets and readily accessibility of this information.It is important to...
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year. Despite the heterogeneity of the ca...
Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
ABSTRACT Primary aldosteronism (PA) is the most common adrenal disorder and the most common cause of endocrine hypertension. PA is associated with cardiovascular morbidity and mort...
Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne Cardiomyopathy
PROJECT SUMMARY Cardiovascular disease is the primary cause of death for patients with Duchenne muscular dystrophy (DMD). Arrhythmia and cardiac fibrosis leading to dilated cardiom...
N-methyl-D-aspartate receptors (NMDAr) participates in renal hemodynamic regulation and blood pressure homeostasis
Abstract Internationally, hypertension is the leading single risk factor for mortality. However, in more than 90% of hypertensive patients, the cause is unknown. There is a critica...
Functional roles of lymphatics in organogenesis and tissue repair
SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies to...
Translational Studies of the Short-Chain Fatty Acid Acetate for Improving Age-Associated Arterial Dysfunction
PROJECT SUMMARY/ABSTRACT The purpose of this K99/R00 application is to provide support for Dr. Vienna Brunt, a promising postdoctoral fellow in the laboratory of Dr. Douglas Seals,...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Investigating multifactorial beta-catenin activation in hepatocellular cancers
Abstract Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options, and lacks molecular- targeted therapies. Activation of Wnt/β-catenin cascade has been...
Chromatin Organization in Glioma Initiation
Project SummaryGlioma is the most common primary brain tumor and represents a disproportionate percentage of cancer fatalities in relationto its incidence. In the last decade, it h...
Proposed roles of KCNQ2 Channels in Respiratory Homeostasis
PROJECT SUMMARY/ABSTRACT KCNQ channels are key determinants of neuronal activity, and recent clinical evidence identifies mutations in KCNQ2 as a cause of neonatal epileptic enceph...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
Functional roles of lymphatics in organogenesis and tissue repair
SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies to...
Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne Cardiomyopathy
PROJECT SUMMARY Cardiovascular disease is the primary cause of death for patients with Duchenne muscular dystrophy (DMD). Arrhythmia and cardiac fibrosis leading to dilated cardiom...
Proposed roles of KCNQ2 Channels in Respiratory Homeostasis
PROJECT SUMMARY/ABSTRACT KCNQ channels are key determinants of neuronal activity, and recent clinical evidence identifies mutations in KCNQ2 as a cause of neonatal epileptic enceph...
Chromatin Organization in Glioma Initiation
Project SummaryGlioma is the most common primary brain tumor and represents a disproportionate percentage of cancer fatalities in relationto its incidence. In the last decade, it h...
Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
ABSTRACT Primary aldosteronism (PA) is the most common adrenal disorder and the most common cause of endocrine hypertension. PA is associated with cardiovascular morbidity and mort...