Browse All Grants
201,169 grants found
Showing 198,241 – 198,260 of 201,169 grants
N-methyl-D-aspartate receptors (NMDAr) participates in renal hemodynamic regulation and blood pressure homeostasis
Abstract Internationally, hypertension is the leading single risk factor for mortality. However, in more than 90% of hypertensive patients, the cause is unknown. There is a critica...
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year. Despite the heterogeneity of the ca...
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year. Despite the heterogeneity of the ca...
Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne Cardiomyopathy
PROJECT SUMMARY Cardiovascular disease is the primary cause of death for patients with Duchenne muscular dystrophy (DMD). Arrhythmia and cardiac fibrosis leading to dilated cardiom...
Functional roles of lymphatics in organogenesis and tissue repair
SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies to...
Understanding and manipulating programmed cell death (PCD) pathways to facilitate lymphoid tumor killing by CAR T cells
PROJECT SUMMARY Recent advances using CAR T cells in lymphoid malignancies have made it clear that manipulation of the host immune system can radically alter the course of a cancer...
N-methyl-D-aspartate receptors (NMDAr) participates in renal hemodynamic regulation and blood pressure homeostasis
Abstract Internationally, hypertension is the leading single risk factor for mortality. However, in more than 90% of hypertensive patients, the cause is unknown. There is a critica...
Primary Aldosteronism Subtypes: Pathophysiology and Steroid Signatures
ABSTRACT Primary aldosteronism (PA) is the most common adrenal disorder and the most common cause of endocrine hypertension. PA is associated with cardiovascular morbidity and mort...
Proposed roles of KCNQ2 Channels in Respiratory Homeostasis
PROJECT SUMMARY/ABSTRACT KCNQ channels are key determinants of neuronal activity, and recent clinical evidence identifies mutations in KCNQ2 as a cause of neonatal epileptic enceph...
Improving the Care Cascade for HIV-associated Kaposi's Sarcoma in sub-Saharan Africa
Project SummaryA subset of patients with coronavirus disease-2019 (COVID-19) develop cutaneous manifestations of theirsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) i...
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME has...
TRD 1 - Imaging Cancer Heterogeneity
Project Summary TRD 1: Imaging Cancer Heterogeneity Precision medicine is a paradigm shift whereby personalized treatment approaches are based on knowledge of an individual’s genot...
TRD 2 - Deep Learning
The goals of the Deep Learning TRD of the Advanced Technologies for the National Center for Image-Guided Therapy (AT-NCIGT) are to investigate revolutionary advances in deep learni...
TRD 3 - Enabling Technologies for Intraprocedural Guidance
ABSTRACT Recent advances in personalized medicine have been accompanied by increasing recognition of image-guided interventions. Two critical needs have to be addressed before imag...
Training & Dissemination
The mission of the AT-NCIGT is to make groundbreaking technological advances in image-guided therapy (IGT). Outreach is a cornerstone of our center. We perform outreach through tra...
Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension
PROJECT SUMMARY Individuals with type II diabetes (T2DM) and metabolic syndrome (MS) display decreased activity of peroxisome proliferator activated receptor gamma (PPARγ) and ofte...
Generation and Dissemination of Enhanced AI/ML-ready Prostate Cancer Imaging Datasets for Public Use
PROJECT SUMMARY Summary of parent grant The Advanced Technologies-National Center for Image guided Therapy (AT-NCIGT) is a research and technology center with the mission of advanc...
Administration Core
The intersection of healthcare and biomedical research is at an inflection point with the convergence of cancer biology combined with new personalized therapies, the digital revolu...
TRD 1 - Imaging Cancer Heterogeneity
Project Summary TRD 1: Imaging Cancer Heterogeneity Precision medicine is a paradigm shift whereby personalized treatment approaches are based on knowledge of an individual’s genot...
Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
ABSTRACT: The intersection of healthcare and biomedical research is at an inflection point with the convergence of the digital revolution, advances in imaging, nanotechnology, big...