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201,169 grants found
Showing 198,261 – 198,280 of 201,169 grants
Administration Core
The intersection of healthcare and biomedical research is at an inflection point with the convergence of cancer biology combined with new personalized therapies, the digital revolu...
TRD 1 - Imaging Cancer Heterogeneity
Project Summary TRD 1: Imaging Cancer Heterogeneity Precision medicine is a paradigm shift whereby personalized treatment approaches are based on knowledge of an individual?s genot...
TRD 2 - Deep Learning
The goals of the Deep Learning TRD of the Advanced Technologies for the National Center for Image-Guided Therapy (AT-NCIGT) are to investigate revolutionary advances in deep learni...
TRD 3 - Enabling Technologies for Intraprocedural Guidance
ABSTRACT Recent advances in personalized medicine have been accompanied by increasing recognition of image-guided interventions.Two critical needs have to be addressed before image...
Training & Dissemination
The mission of the AT-NCIGT is to make groundbreaking technological advances in image-guided therapy (IGT). Outreach is a cornerstone of our center.We perform outreach through trai...
The Role of PHF6 in HSC self-renewal and myeloid expansion
Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal....
Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension
PROJECT SUMMARY Individuals with type II diabetes (T2DM) and metabolic syndrome (MS) display decreased activity of peroxisome proliferator activated receptor gamma (PPAR?) and ofte...
Live Imaging of Immunity to M. tuberculosis
Project Summary Tuberculosis (TB), caused by the bacterium, Mycobacterium tuberculosis, kills more humans every year than does any other infectious disease, including HIV. Among th...
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo.Tissue eng...
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME has...
Neural control of pancreatic endocrine function in obesity and diabetes
Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity.We will create a detailed and systemic view of defined pancreatic nerves, t...
Immune response to inhalation of live attenuated vaccine in an outbred tularemia model (Resubmission)
Tularemia is a severe zoonotic disease in humans with fatality rates exceeding 30% in untreated subjects.Francisella tularensis, the causative organism, is a gram-negative coccobac...
Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
ABSTRACT: The intersection of healthcare and biomedical research is at an inflection point with the convergence of the digital revolution, advances in imaging, nanotechnology, big...
Administration Core
The intersection of healthcare and biomedical research is at an inflection point with the convergence of cancer biology combined with new personalized therapies, the digital revolu...
Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension
PROJECT SUMMARY Individuals with type II diabetes (T2DM) and metabolic syndrome (MS) display decreased activity of peroxisome proliferator activated receptor gamma (PPARγ) and ofte...
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME has...
The Role of PHF6 in HSC self-renewal and myeloid expansion
Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal....
Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
ABSTRACT: The intersection of healthcare and biomedical research is at an inflection point with the convergence of the digital revolution, advances in imaging, nanotechnology, big...
Administration Core
The intersection of healthcare and biomedical research is at an inflection point with the convergence of cancer biology combined with new personalized therapies, the digital revolu...
TRD 1 - Imaging Cancer Heterogeneity
Project Summary TRD 1: Imaging Cancer Heterogeneity Precision medicine is a paradigm shift whereby personalized treatment approaches are based on knowledge of an individual’s genot...