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Showing 198,281198,300 of 201,169 grants

Completed RESEARCH CENTERS
TRD 2 - Deep Learning
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

The goals of the Deep Learning TRD of the Advanced Technologies for the National Center for Image-Guided Therapy (AT-NCIGT) are to investigate revolutionary advances in deep learni...

Completed RESEARCH CENTERS
TRD 3 - Enabling Technologies for Intraprocedural Guidance
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

ABSTRACT Recent advances in personalized medicine have been accompanied by increasing recognition of image-guided interventions. Two critical needs have to be addressed before imag...

Completed RESEARCH CENTERS
Training & Dissemination
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

The mission of the AT-NCIGT is to make groundbreaking technological advances in image-guided therapy (IGT). Outreach is a cornerstone of our center. We perform outreach through tra...

Completed RESEARCH CENTERS
TRD 2 - Deep Learning
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

The goals of the Deep Learning TRD of the Advanced Technologies for the National Center for Image-Guided Therapy (AT-NCIGT) are to investigate revolutionary advances in deep learni...

Completed RESEARCH CENTERS
TRD 3 - Enabling Technologies for Intraprocedural Guidance
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

ABSTRACT Recent advances in personalized medicine have been accompanied by increasing recognition of image-guided interventions. Two critical needs have to be addressed before imag...

Completed OTHER RESEARCH-RELATED
INCIDENCE, PREDICTORS, AND CLINICAL OUTCOMES OF SARS-CoV-2 INFECTION IN PERSONS WITH HIV
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Alabama At Birmingham United States 2021 – 2021

Clinical manifestations and severity of COVID-19, the disease caused by SARS-CoV-2, in persons with HIV (PWH) have not been described in the United States (US).It is of critical im...

$1.87M
USD
Completed NON-SBIR/STTR RPGS
The Role of PHF6 in HSC self-renewal and myeloid expansion
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Pennsylvania United States 2021 – 2024

Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal....

$5.51M
USD
Completed NON-SBIR/STTR RPGS
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Michigan State University United States 2021 – 2024

Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue en...

$4.75M
USD
Completed NON-SBIR/STTR RPGS
Neural control of pancreatic endocrine function in obesity and diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2021 – 2024

Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity.We will create a detailed and systemic view of defined pancreatic nerves, t...

$5.95M
USD
Completed NON-SBIR/STTR RPGS
Live Imaging of Immunity to M. tuberculosis
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of California, San Francisco United States 2021 – 2023

Project Summary Tuberculosis (TB), caused by the bacterium, Mycobacterium tuberculosis, kills more humans every year than does any other infectious disease, including HIV. Among th...

$1.01M
USD
Completed NON-SBIR/STTR RPGS
Immune response to inhalation of live attenuated vaccine in an outbred tularemia model (Resubmission)
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... University of Pittsburgh At Pittsburgh United States 2021 – 2024

Tularemia is a severe zoonotic disease in humans with fatality rates exceeding 30% in untreated subjects. Francisella tularensis, the causative organism, is a gram-negative coccoba...

$2.23M
USD
Completed NON-SBIR/STTR RPGS
Neural control of pancreatic endocrine function in obesity and diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2021 – 2024

Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity.We will create a detailed and systemic view of defined pancreatic nerves, t...

$5.95M
USD
Completed NON-SBIR/STTR RPGS
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Michigan State University United States 2021 – 2024

Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue en...

$4.45M
USD
Completed RESEARCH CENTERS
Administration Core
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

The intersection of healthcare and biomedical research is at an inflection point with the convergence of cancer biology combined with new personalized therapies, the digital revolu...

Completed NON-SBIR/STTR RPGS
Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Michigan State University United States 2021 – 2025

Project Abstract This grant proposes both an innovative contrast agent and X-ray computed tomography (CT) imaging method for monitoring implantable biomaterials, in vivo. Tissue en...

$4.54M
USD
Completed OTHER RESEARCH-RELATED
Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... University of Rochester United States 2021 – 2025

PROJECT SUMMARY Individuals with type II diabetes (T2DM) and metabolic syndrome (MS) display decreased activity of peroxisome proliferator activated receptor gamma (PPARγ) and ofte...

$1.54M
USD
Completed NON-SBIR/STTR RPGS
The Role of PHF6 in HSC self-renewal and myeloid expansion
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Pennsylvania United States 2021 – 2025

Abstract / Project Summary Hematopoietic stem cells (HSCs) require fine-tuned cooperation of transcription factors (TFs) and epigenetic regulators to maintain normal self-renewal....

$5.22M
USD
Completed NON-SBIR/STTR RPGS
Neural control of pancreatic endocrine function in obesity and diabetes
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND K... Icahn School of Medicine At Mount Sinai United States 2021 – 2025

Our long-term goal is to enable diabetes treatments through precise control of pancreatic nerve activity.We will create a detailed and systemic view of defined pancreatic nerves, t...

$5.71M
USD
Completed NON-SBIR/STTR RPGS
Regulation and Function of Alternative mRNA Isoform Expression in Mammals
NATIONAL HUMAN GENOME RESEARCH INSTITUTE Massachusetts Institute of Technology United States 2021 – 2025

Summary Most human genes contain introns, and presence of introns often increases the expression of the host gene, a phenomenon known as intron-mediated enhancement (IME). IME has...

$5.28M
USD
Completed RESEARCH CENTERS
Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)
NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOEN... Brigham and Women'S Hospital United States 2021 – 2025

ABSTRACT: The intersection of healthcare and biomedical research is at an inflection point with the convergence of the digital revolution, advances in imaging, nanotechnology, big...

$13.91M
USD