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201,169 grants found
Showing 198,341 – 198,360 of 201,169 grants
Molecular mechanisms of NFIB in small cell lung cancer metastasis
PROJECT SUMMARY Most cancer patients do not die from their primary tumor but from their metastases.In spite of the morbidity and mortality associated with metastatic disease, relat...
Thermodynamic and Allosteric Basis of Paradoxical Activation in V600E Mutant BRAF Cancers
PROJECT SUMMARY The activating V600E mutation in the protein kinase BRAF is a well-established driver of human cancer.The effectiveness of current BRAF inhibitors developed to targ...
Investigating the Role of DNMT3A mutations in the initiation and maintenance of myeloid malignancies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is an aggressive malignancy with a poor prognosis, owing in part to substantial intratumor genetic heterogeneity that allows s...
Link, transport, integrate: a Bayesian data integration framework for scalable algorithmic dementia classification in population-representative studies
Project Summary Nationally representative cohorts are crucial for monitoring population trends in incidence, prevalence, and disparities in Alzheimer?s disease (AD) and Alzheimer?s...
The Role of Klotho Beta in Colorectal Cancer Tumorigenesis
Abstract Colorectal cancer (CRC) is both the third most common and deadliest cancer in the United States.Despite recent advances in treatment, the 5-year survival rate remains poor...
The Role of Klotho Beta in Colorectal Cancer Tumorigenesis
Abstract Colorectal cancer (CRC) is both the third most common and deadliest cancer in the United States. Despite recent advances in treatment, the 5-year survival rate remains poo...
Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome
PROJECT SUMMARY. Despite knowing for more than 60-years that three copies of chromosome 21 (chr21, T21) is the genetic cause of Down syndrome (DS), we still know relatively little...
An Integrated Drug Discovery Consortium for NTDs (IDDC-NTD)
The long-term significance of the proposed IDDC-NTD will manifest in new treatment options for those suffering from neglected tropical diseases, particularly those in developing na...
Task B19: Synthesis of LpxC Inhibitors with Improved Physicochemical Properties
This task provides for lead identification, development, chemistry and synthesis services under the NIAID Preclinical Services for the Development of Interventional Agents Program.
Task B20: Synthesis or acquisition of 7-Deaza-2'-C-Methyladenosine for animal studies
This task provides for lead identification, development, chemistry and synthesis services under the NIAID Preclinical Services for the Development of Interventional Agents Program.
Investigating the Role of DNMT3A mutations in the initiation and maintenance of myeloid malignancies
PROJECT SUMMARY/ABSTRACT Acute myeloid leukemia (AML) is an aggressive malignancy with a poor prognosis, owing in part to substantial intratumor genetic heterogeneity that allows s...
Determining the role of LSD1 in multiple myeloma through a multi-omics approach at single cell resolution
PROJECT SUMMARY / ABSTRACT Multiple myeloma (MM) kills nearly 13,000 people annually in the United States1. MM is preceded by a less life- threating blood condition, which is simil...
The Role of Klotho Beta in Colorectal Cancer Tumorigenesis
Abstract Colorectal cancer (CRC) is both the third most common and deadliest cancer in the United States. Despite recent advances in treatment, the 5-year survival rate remains poo...
Defining the Role of DNA Rereplication of Chromosome 21 in the Development and Pathophysiology of Down Syndrome
PROJECT SUMMARY.Despite knowing for more than 60-years that three copies of chromosome 21 (chr21, T21) is the genetic cause of Down syndrome (DS), we still know relatively little a...
Defining the roles of an enhancer long non-coding RNA eIncRNA-ID2 in rickettsial pathogenesis and immunity
PROJECT SUMMARY Precise and dynamic alterations in gene expression are critical determinants of the regulation of host immunity to microbial pathogens.Pathogenic rickettsiae in the...
Determining the role of LSD1 in multiple myeloma through a multi-omics approach at single cell resolution
PROJECT SUMMARY / ABSTRACT Multiple myeloma (MM) kills nearly 13,000 people annually in the United States1.MM is preceded by a less life- threating blood condition, which is simila...
Molecular Mechanisms of Susceptibility to Drug Use
PROJECT SUMMARY / ABSTRACT The transition from drug use to abuse and, eventually, to dependence may be mediated by biological factors that are present prior to drug use.Although ch...
Thermodynamic and Allosteric Basis of Paradoxical Activation in V600E Mutant BRAF Cancers
PROJECT SUMMARY The activating V600E mutation in the protein kinase BRAF is a well-established driver of human cancer. The effectiveness of current BRAF inhibitors developed to tar...
Defining the roles of an enhancer long non-coding RNA eIncRNA-ID2 in rickettsial pathogenesis and immunity
PROJECT SUMMARY Precise and dynamic alterations in gene expression are critical determinants of the regulation of host immunity to microbial pathogens. Pathogenic rickettsiae in th...
The Impact of Gut Microbiota on the Sex Difference in Bladder Cancer
Men are 3-5 times more likely than women to develop and die from bladder cancer (BCa) but the underlying mechanisms of these gender disparities in BCa are poorly understood. This i...