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201,169 grants found
Showing 198,401 – 198,420 of 201,169 grants
Integrated NMR for Complex Systems
TR&D 3 SUMMARY Assigning each resonance in an NMR spectrum to individual atoms in a molecule is essential to almost every NMR project. Automated programs are successful for ass...
Driving Biomedical Projects
DRIVING BIOMEDICAL PROJECTS SUMMARY Development of new technology is driven by the desire to perform experiments for which the tools do not yet exist. Our driving biomedical projec...
Community Engagement
COMMUNITY ENGAGEMENT SUMMARY NMRFAM has a long history of providing service and access to new technology to the NMR community. We continue this tradition as we move into new techno...
Exploration of a Novel Therapeutic for Alzheimer's Disease and Related Disorders
?Exploration of a Novel Therapeutic for Alzheimer?s Disease and Related Disorders?Project Summary / Abstract Neurodegenerative disorders are responsible for progressive loss of syn...
NMR Technologies for Integrating Structure, Function and Disease
INTRODUCTION TO REVISED APPLICATION The A0 grant was submitted in May 2019, before Prof. Alexander Barnes moved to ETH-Zurich and before Prof. Chad Rienstra was recruited to UW-Mad...
Administration and Management
ADMINISTRATION AND MANAGEMENT SUMMARY Our goal is to develop a plan for administration and management to ensure that the biotechnology research resource operates productively and e...
Expanding the Scope of NMR Sample Preparation
TR&D 1 SUMMARY This technology research and development project targets two major challenges for solid-state NMR and structural biology. First, sample handling represents a maj...
Technologies for Solid-State NMR Data Collection
TR&D 2 SUMMARY The overall performance of the NMR spectrometer impacts every research sample and outcome. Often for complex multidimensional magic-angle spinning solid-state NM...
Integrated NMR for Complex Systems
TR&D 3 SUMMARY Assigning each resonance in an NMR spectrum to individual atoms in a molecule is essential to almost every NMR project. Automated programs are successful for ass...
Next generation deep tissue quantitative optical imaging
PROJECT SUMMARY Nearly 20-years of clinical research has shown that near-infrared optical imaging based upon frequency domain diffuse optical spectroscopy (FD-DOS) can be a powerfu...
Molecular functions of human zinc transporter-8 in pancreatic beta cells
Abstract Zinc is a ubiquitous biological metal found in about 10% of the eukaryotic proteome.The spatiotemporal zinc dynamics provides crucial cellular signaling opportunities, but...
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION
Inflammatory macrophages play a key role in the development and progression of the atherosclerosis, leading to myocardial infarction (MI). Sphingolipids are both membrane component...
Tissue Damage-Driven Squamous Cell Carcinoma
Squamous cell carcinoma (SCC) is responsible for ~10% of total cancer mortality worldwide.SCC prognosis is context-dependent and does not seem to be determined by driver gene somat...
Noninvasive measurement of oxygenation using quantitative susceptibility mapping
PROJECT SUMMARY/ABSTRACT The goal of this research is to develop cardiac quantitative susceptibility mapping (QSM) for non-invasive meas- urement of blood oxygen saturation, toward...
Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell disease
Project Summary Silent cerebral infarction is a serious consequence of sickle cell disease (SCD), affecting ~40% of patients by age 15.Although these injuries accumulate occultly,...
Effects of Acute Exercise on Functional Magnetic Resonance Spectroscopy Measures of GABA in Aging and Chronic Stroke
The current proposal seeks to index the effect of acute aerobic exercise on excitatory and inhibitory balance using magnetic resonance spectroscopy (MRS) in aging and in chronic st...
Molecular mechanisms of excitatory postsynaptic diversity
Unique patterns of synaptic connectivity between neurons, and the differential strength of those synapses, are fundamental to the information processing capability of the brain.Syn...
Using nicotine to reverse age-related auditory processing deficits
Age-related decline in central auditory function significantly affects quality of life in the elderly, with impaired speech perception leading to increased risk for depression, soc...
Phase 2 Study of Theophylline for the Treatment of Psuedohypoparathyroidism
Pseudohypoparathyroidism (PHP) is a rare, genetic disorder caused by impaired stimulatory G protein (Gs?) signaling through downregulation of the gene, GNAS.The resultant hormone a...
Medicating distress: Use of psychotropic medications among patients with dementia receiving hospice care
ABSTRACT The goal of this Mentored Career Development Award is to prepare Dr.Lauren Gerlach for a career as an independent investigator focused on measuring and improving the quali...